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Risk of psychiatric diseases among patients with psoriasis in Korea: A 12-year nationwide population-based cohort study

Authors
 Jongwook Oh  ;  Keum Ji Jung  ;  Tae-Gyun Kim  ;  Hae Won Kim  ;  Sun Ha Jee  ;  Min-Geol Lee 
Citation
 JOURNAL OF DERMATOLOGY, Vol.48(11) : 1763-1771, 2021-11 
Journal Title
JOURNAL OF DERMATOLOGY
ISSN
 0385-2407 
Issue Date
2021-11
MeSH
Cohort Studies ; Humans ; Incidence ; Mental Disorders* / epidemiology ; Proportional Hazards Models ; Psoriasis* / epidemiology ; Republic of Korea / epidemiology ; Risk Factors
Keywords
Korean ; cohort study ; comorbidity ; psoriasis ; psychiatric diseases
Abstract
The association between psoriasis and risk of psychiatric diseases has not been thoroughly evaluated in a large longitudinal cohort of the Asian population. We conducted a nationwide cohort study encompassing more than 1.6 million Koreans with a 12-year follow-up period. Patients were considered to be in the psoriasis cohort if they had an incident diagnostic code for psoriasis and included patients were followed up until they developed any psychiatric disease. In adjusted models, psoriasis patients (n = 10 868) were at an 18% increased risk for depression (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.09-1.26), 16% for anxiety disorders (HR, 1.16; 95% CI, 1.08-1.26), and 21% for somatoform disorders (HR, 1.21; 95% CI, 1.08-1.34) compared with the referent cohort (n = 1 620 055). Patients with moderate-to-severe psoriasis had a higher risk of developing depression and somatoform disorders than patient with mild disease (depression, HR, 1.28; 95% CI, 1.07-1.54 vs HR, 1.17; 95% CI, 1.07-1.27; somatoform disorders, HR, 1.60; 95% CI, 1.26-2.03 vs HR, 1.13; 95% CI, 1.00-1.28). Our results highlight the burden of psychiatric diseases in patients with psoriasis in Korea and suggest that appropriate medical support for possible mental illness is warranted in Asian psoriatic patients.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/1346-8138.16115
DOI
10.1111/1346-8138.16115
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Kim, Hae Won(김혜원) ORCID logo https://orcid.org/0000-0002-9321-8361
Oh, Jongwook(오종욱)
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188169
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