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Meibomian gland atrophy with duration of Sjogren's syndrome in adult females

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dc.contributor.author서경률-
dc.contributor.author서경률-
dc.date.accessioned2022-03-11T06:21:44Z-
dc.date.available2022-03-11T06:21:44Z-
dc.date.issued2022-01-
dc.identifier.issn0165-5701-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188052-
dc.description.abstractBackground: To investigate the correlation between the duration of Sjögren syndrome (SS) and ocular surface parameters in patients with SS-related dry eye. Methods: We analyzed 108 eyes of 108 female patients with primary SS-related dry eye. All patients underwent rheumatoid serologic tests and ocular surface assessments. The ocular surface assessment included the Standard Patient Evaluation of Eye Dryness (SPEED) score, meibomian gland (MG) atrophy, lipid layer thickness (LLT), partial and total blinking, partial blinking rate, Schirmer's I test, non-invasive tear break-up time, and ocular surface staining score. Correlations between the duration of SS and ocular surface assessments were calculated. Results: The average age and SS duration of the participants were 56.7 ± 10.2 (range 21-78) years and 54.15 ± 41.10 (range 1-134) months, respectively. There was a strong positive correlation between SS duration and MG atrophy (r = 0.766, p < 0.001). The correlation between SS duration and MG atrophy rate remained significant after controlling for age (r = 0.559, p < 0.001). Average, maximum, and minimum LLTs showed weak negative correlations with SS duration (r = - 0.310, - 0.211, and-0.304, respectively, p = 0.014, 0.028, and 0.022, respectively) and MG atrophy (r = - 0.191, - 0.326, and - 0.299, respectively, p = 0.049, 0.002, and 0.009, respectively). SPEED score showed a weak positive correlation to SS duration (r = 0.303, p = 0.042) and a moderate positive correlation to MG atrophy (r = 0.450, p = 0.029). Conclusions: Longer duration of primary SS was related to more severe MG atrophy. Therefore, it is necessary to perform meibography in SS patients to verify MG atrophy status. A comparative study with non-SS dry eye patients is required to validate this study.-
dc.description.statementOfResponsibilityrestriction-
dc.languageINTERNATIONAL OPHTHALMOLOGY-
dc.publisherINTERNATIONAL OPHTHALMOLOGY-
dc.relation.isPartOfINTERNATIONAL OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAtrophy / pathology-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDry Eye Syndromes* / diagnosis-
dc.subject.MESHDry Eye Syndromes* / etiology-
dc.subject.MESHDry Eye Syndromes* / pathology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMeibomian Glands / pathology-
dc.subject.MESHSjogren's Syndrome* / complications-
dc.subject.MESHSjogren's Syndrome* / diagnosis-
dc.subject.MESHTears-
dc.titleMeibomian gland atrophy with duration of Sjogren's syndrome in adult females-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorSung Rae Noh-
dc.contributor.googleauthorJae Lim Chung-
dc.contributor.googleauthorJeong Min Lee-
dc.contributor.googleauthorKyoung Yul Seo-
dc.contributor.googleauthorKyungmin Koh-
dc.identifier.doi10.1007/s10792-021-02013-7-
dc.contributor.localIdA01870-
dc.contributor.localIdA01870-
dc.relation.journalcodeJ03616-
dc.identifier.pmid34409540-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s10792-021-02013-7-
dc.subject.keywordDry eye disease-
dc.subject.keywordMeibomian gland atrophy-
dc.subject.keywordSjögren syndrome-
dc.contributor.alternativeNameSeo, Kyoung Yul-
dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor서경률-
dc.citation.volume42-
dc.citation.number1-
dc.citation.startPage191-
dc.citation.endPage200-
dc.identifier.bibliographicCitationINTERNATIONAL OPHTHALMOLOGY , Vol.42(1) : 191-200, 2022-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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