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Treatment of Human Immunodeficiency Virus-Associated Facial Lipoatrophy With Hyaluronic Acid Filler Mixed With Micronized Cross-Linked Acellular Dermal Matrix

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dc.contributor.author김제민-
dc.contributor.author송승용-
dc.contributor.author이영인-
dc.contributor.author이주희-
dc.contributor.author최준용-
dc.date.accessioned2022-03-11T06:17:03Z-
dc.date.available2022-03-11T06:17:03Z-
dc.date.issued2022-02-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188020-
dc.description.abstractBackground: Human immunodeficiency virus (HIV)-associated facial lipoatrophy (FLA) is a stigmatizing side effect associated with the use of highly active antiretroviral therapy. We sought to evaluate the safety and efficacy of the hyaluronic acid filler mixed with micronized cross-linked acellular dermal matrix (HA/MADM) in HIV-associated FLA. Methods: We conducted an open-label safety and efficacy study in patients with HIV-associated FLA. Fourteen patients received single injection of the HA/MADM, and 13 patients completed the 24-week follow-up evaluation. Treatment efficacy, safety, and patient and physician satisfaction were evaluated. Repeated measure analysis of variance with post-hoc analysis with the Wilcoxon signed rank test was performed to compare and incorporate parameters at each time point. Results: All 13 patients maintained a significant improvement of the Carruthers Lipoatrophy Severity Scale grade throughout the study period, along with improvement of the depressed volume due to lipoatrophy measured using a three-dimensional camera system. More than 80% of patients and physicians were satisfied with the treatment, and no treatment-related adverse events were reported, except for one case of transient subcutaneous nodule formation. Conclusion: Our study findings suggest that injectable HA/MADM is a potentially effective and safe treatment option for treating HIV-positive patients with FLA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTreatment of Human Immunodeficiency Virus-Associated Facial Lipoatrophy With Hyaluronic Acid Filler Mixed With Micronized Cross-Linked Acellular Dermal Matrix-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorJemin Kim-
dc.contributor.googleauthorSeung Yong Song-
dc.contributor.googleauthorSang Gyu Lee-
dc.contributor.googleauthorSooyeon Choi-
dc.contributor.googleauthorYoung In Lee-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorJu Hee Lee-
dc.identifier.doi10.3346/jkms.2022.37.e37-
dc.contributor.localIdA05725-
dc.contributor.localIdA02032-
dc.contributor.localIdA05880-
dc.contributor.localIdA03171-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid35132843-
dc.subject.keywordDermal Fillers-
dc.subject.keywordHIV-
dc.subject.keywordLipoatrophy-
dc.contributor.alternativeNameKim, Jemin-
dc.contributor.affiliatedAuthor김제민-
dc.contributor.affiliatedAuthor송승용-
dc.contributor.affiliatedAuthor이영인-
dc.contributor.affiliatedAuthor이주희-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume37-
dc.citation.number5-
dc.citation.startPagee37-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.37(5) : e37, 2022-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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