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Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group

Authors
 Kyung Mi Park  ;  Keon Hee Yoo  ;  Seong Koo Kim  ;  Jae Wook Lee  ;  Nack-Gyun Chung  ;  Hee Young Ju  ;  Hong Hoe Koo  ;  Chuhl Joo Lyu  ;  Seung Min Han  ;  Jung Woo Han  ;  Jung Yoon Choi  ;  Kyung Taek Hong  ;  Hyoung Jin Kang  ;  Hee Young Shin  ;  Ho Joon Im  ;  Kyung-Nam Koh  ;  Hyery Kim  ;  Hoon Kook  ;  Hee Jo Baek  ;  Bo Ram Kim  ;  Eu Jeen Yang  ;  Jae Young Lim  ;  Eun Sil Park  ;  Eun Jin Choi  ;  Sang Kyu Park  ;  Jae Min Lee  ;  Ye Jee Shim  ;  Ji Yoon Kim  ;  Ji Kyoung Park  ;  Seom Gim Kong  ;  Young Bae Choi  ;  Bin Cho  ;  Young Tak Lim 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.54(1) : 269-276, 2022-01 
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
 1598-2998 
Issue Date
2022-01
Keywords
Acute promyelocytic leukemia ; All-trans retinoic acid ; Childhood
Abstract
Purpose: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea.

Materials and methods: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively.

Results: Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020).

Conclusion: This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.
Files in This Item:
T202200417.pdf Download
DOI
10.4143/crt.2021.313
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Hahn, Seung Min(한승민) ORCID logo https://orcid.org/0000-0001-9832-6380
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188004
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