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The impact of neonatal morbidities on child growth and developmental outcomes in very low birth weight infants: a nationwide cohort study

Authors
 Jung Ho Han  ;  So Jin Yoon  ;  Joo Hee Lim  ;  Jeong Eun Shin  ;  Ho Seon Eun  ;  Min Soo Park  ;  Kook In Park  ;  Soon Min Lee 
Citation
 EUROPEAN JOURNAL OF PEDIATRICS, Vol.181(1) : 197-205, 2022-01 
Journal Title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN
 0340-6199 
Issue Date
2022-01
MeSH
Birth Weight ; Child ; Cohort Studies ; Humans ; Infant ; Infant, Newborn ; Infant, Premature* ; Infant, Very Low Birth Weight ; Morbidity ; Premature Birth*
Keywords
Growth ; Morbidities ; Neurodevelopmental outcomes ; Very low birth weight
Abstract
Growth in preterm infants has long-term implications for neurodevelopmental outcomes. We aimed to estimate the nationwide growth outcomes from birth to 5 years in infants born under 1500 g and to analyze the effects of major morbidities in preterm infants on growth. In total, 2961 children born in 2013 with a birth weight under 1500 g who underwent an infant health checkup between 2013 and 2018 according to the National Health Insurance Service database were included. Checkups were conducted at 4-6, 9-12, 18-24, 30-36, 42-48, and 54-60 months of age. Information was obtained from the International Classification of Diseases-10 codes or a questionnaire administered during the check-up. At 60 months of age, the mean percentiles of weight, height, and head circumference fell within only the 30-40th percentile of normal growth values. About 30% of infants had growth parameters below the 10th percentile and showed worse neurodevelopmental outcomes. Using multiple logistic regression, infants with bronchopulmonary dysplasia showed a significantly higher incidence of growth restriction in all three categories of weight (odds ratio [OR] 1.50), height (OR 1.33), and head circumference (OR 1.36) at 60 months. Sepsis was associated with growth restriction in weight (OR 1.43) and head circumference (OR 1.33). Periventricular leukomalacia infants had relatively small head circumferences (OR 1.91) and poor developmental screening results (OR 2.89).Conclusion: Catch-up growth remains a major issue in infants born under 1500 g, especially those with some morbidities from preterm birth. Regular checkups to monitor and early intervention to achieve normal growth are essential. What is Known: • Growth in preterm infants has long-term implications for neurodevelopmental and cardiometabolic outcomes. • Data are lacking on the time-serial effects of many preterm morbidities simultaneously on long-term growth outcomes. What is New: • All growth parameters of VLBW infants, including weight, height, and head circumference, fell within the 30-40th percentile of normal growth for infants at 60 months of age, indicating that catch-up growth for VLBW infants remains an issue. • VLBW infants with major preterm morbidities, including BPD, PVL, and sepsis, showed difficulties in achieving normal catch-up growth and neurodevelopment at 60 months of age.
Full Text
https://link.springer.com/article/10.1007/s00431-021-04177-x
DOI
10.1007/s00431-021-04177-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
Yoon, So Jin(윤소진) ORCID logo https://orcid.org/0000-0002-7028-7217
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
Lim, Joo Hee(임주희) ORCID logo https://orcid.org/0000-0003-4376-6607
Han, Jung Ho(한정호) ORCID logo https://orcid.org/0000-0001-6661-8127
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187937
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