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GeTe Nanosheets as Theranostic Agents for Multimodal Imaging and Therapy of Inflammatory Bowel Disease

Authors
 Jun Ho Song  ;  Taejun Yoon  ;  Sun-Mi Lee  ;  Chin Hee Mun  ;  Dasol Kim  ;  Jieun Han  ;  Ju-Won Kim  ;  Yonghee Bae  ;  Taehee Kim  ;  Young Nyun Park  ;  Mann-Ho Cho  ;  Yong-Beom Park  ;  Kyung-Hwa Yoo 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.32(2) : 2107433, 2022-01 
Journal Title
ADVANCED FUNCTIONAL MATERIALS
ISSN
 1616-301X 
Issue Date
2022-01
Abstract
Recently, 2D nanomaterials have received considerable attention in nanomedicine due to their intrinsic optical properties, biocompatibility, and therapeutic effect. Here, 2D germanium telluride (GeTe) nanosheets coated with polyvinylpyrrolidone (PVP) (GeTe-PVP NSs) developed as theranostic agents are reported that can be used for multispectral optoacoustic tomography (MSOT) and fluorescence imaging and therapy of inflammatory bowel disease (IBD). GeTe-PVP NSs, fabricated by simple sonication in ethanol and PVP, show broad optical absorption in visible and near-infrared (NIR) ranges (400–1200 nm) and have intrinsic fluorescence properties. Thus, they provide deeper ex vivo and in vivo MSOT tissue images than gold nanorods or indocyanine green with strong optical absorption in the first NIR window (700–900 nm). In addition, when orally administered to IBD mice, GeTe-PVP NSs exhibit therapeutic efficacy similar to or higher than sulfasalazine, with strong accumulation at inflammatory colon sites. This demonstrates that oral administration of GeTe-PVP NSs may be used to treat inflammatory diseases in the gastrointestinal tract.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202107433
DOI
10.1002/adfm.202107433
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Yong Beom(박용범)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187901
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