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Association of MGMT Gene Promoter Methylation With Clinicopathological Parameters in Patients With Wild-type IDH Glioblastoma

Authors
 Moonsik Kim  ;  Jihwan Yoo  ;  Jong Hee Chang  ;  Se Hoon Kim 
Citation
 ANTICANCER RESEARCH, Vol.42(1) : 335-341, 2022-01 
Journal Title
ANTICANCER RESEARCH
ISSN
 0250-7005 
Issue Date
2022-01
Keywords
ATRX loss ; MGMT ; glioblastoma ; hypermethylation ; low methylation ; methylation status ; temozolomide chemotherapy ; wild-type IDH
Abstract
Background: The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter plays a key role in response to temozolomide chemotherapy and disease prognosis in patients with wild-type isocitrate dehydrogenase (IDH) glioblastoma (GBM).

Patients and methods: The MGMT promoter methylation status and its association with clinicopathological parameters were retrospectively analysed in a cohort of 316 patients with GBM with wild-type IDH.

Results: MGMT methylation was significantly associated with ATRX chromatin remodeler (ATRX) loss and completion of the standard Stupp protocol. The median durations of overall and progression-free survival for the unmethylated, low-methylated (10-39%), and hypermethylated (≥40%) groups were 15, 23, and 30 months and 11, 18, and 21 months, respectively. However, the improvement in the survival of the hypermethylated group was not statistically significant.

Conclusion: We suggest a possible association between MGMT methylation status and ATRX mutations in GBM with wild-type IDH.
Full Text
https://ar.iiarjournals.org/content/42/1/335.long
DOI
10.21873/anticanres.15490
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Yoo, Jihwan(유지환)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187862
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