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Potential threats of nanoplastic accumulation in human induced pluripotent stem cells

Authors
 Hyejoong Jeong  ;  Wijin Kim  ;  Daheui Choi  ;  Jiwoong Heo  ;  Uiyoung Han  ;  Se Yong Jung  ;  Hee Ho Park  ;  Sung-Tae Hong  ;  Ju Hyun Park  ;  Jinkee Hong 
Citation
 CHEMICAL ENGINEERING JOURNAL, Vol.427(1) : 131841, 2022-01 
Journal Title
CHEMICAL ENGINEERING JOURNAL
ISSN
 1385-8947 
Issue Date
2022-01
Keywords
Microplastic ; Nanoplastic ; Long-term toxicity ; Bioaccumulation ; Induced Pluripotent Stem Cell ; Developmental toxicology
Abstract
The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a long-term. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.
Full Text
https://www.sciencedirect.com/science/article/pii/S1385894721034185
DOI
10.1016/j.cej.2021.131841
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Se Yong(정세용) ORCID logo https://orcid.org/0000-0003-1337-563X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187841
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