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Consensus Update for Systemic Treatment of Atopic Dermatitis

 Ji Hyun Lee  ;  Jung Eun Kim  ;  Gyeong-Hun Park  ;  Jung Min Bae  ;  Ji Yeon Byun  ;  Min Kyung Shin  ;  Tae Young Han  ;  Seung Phil Hong  ;  Yong Hyun Jang  ;  Hye One Kim  ;  Chan Ho Na  ;  Bark-Lynn Lew  ;  JiYoung Ahn  ;  Chang Ook Park  ;  Young-Joon Seo  ;  Yang Won Lee  ;  Sang Wook Son  ;  Eung Ho Choi  ;  Young Lip Park  ;  Joo Young Roh 
 ANNALS OF DERMATOLOGY, Vol.33(6) : 497-514, 2021-12 
Journal Title
Issue Date
Atopic dermatitis ; Consensus ; Republic of Korea ; Systemic treatment ; Therapeutics
Background: In 2015, the Korean Atopic Dermatitis Association (KADA) working group published consensus guidelines for treating atopic dermatitis (AD).

Objective: We aimed to provide updated consensus recommendations for systemic treatment of AD in South Korea based on recent evidence and experience.

Methods: We compiled a database of references from relevant systematic reviews and guidelines on the systemic management of AD. Evidence for each statement was graded and classified based on thestrength of the recommendation. Forty-two council members from the KADA participated in three rounds of voting to establish a consensus on expert recommendations.

Results: We do not recommend long-term treatment with systemic steroids forpatients with moderate-to-severe AD due to the risk of adverse effects. We recommend treatment with cyclosporine or dupilumab and selective treatment with methotrexate or azathioprine for patients with moderate-to-severe AD. We suggest treatment with antihistamines as an option for alleviating clinical symptoms of AD. We recommend selective treatment with narrowband ultraviolet B for patients with chronic moderate-to-severe AD. We do not recommend treatment with oral antibiotics for patients with moderate-to-severe AD but who have no signs of infection. We did not reach a consensus on recommendations for treatment with allergen-specific immunotherapy, probiotics, evening primrose oil, orvitamin D for patients with moderate-to-severe AD. We also recommend educational interventions and counselling for patients with AD and caregivers to improve the treatment success rate.

Conclusion: We look forward to implementing a new and updated consensus of systemic therapy in controlling patients with moderate-to-severe AD.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
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