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Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report

Authors
 Tae-Wook Ha  ;  Slmaro Park  ;  Min Yeong Youn  ;  Dong Wook Kim  ;  Hyung Jun Kim 
Citation
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.47(4) : 315-320, 2021-08 
Journal Title
Journal of the Korean Association of Oral and Maxillofacial Surgeons(대한구강악안면외과학회지)
ISSN
 2234-7550 
Issue Date
2021-08
Keywords
Head and neck neoplasms ; Heavy ion radiotherapy ; Osteosarcoma ; Radiotherapy
Abstract
Carbon-ion radiotherapy (CIRT) is on the rise as a treatment choice for malignant tumor. Compared to conventional radiotherapy, particle beams have different physical and biological properties. Particle beam provides a low entry dose, deposits most of the energy at the endpoint of the flight path, and forms an asymptotic dose peak (the "Bragg peak"). Compared to protons, carbon with its larger mass decreases beam scattering, resulting in a sharper dose distribution border. We report a 50-year-old male who underwent CIRT without surgical resection on osteosarcoma of the mandible. After CIRT, the patient's pain was gone, and the malignant mass remained stable with accompanying necrosis. Nine months later, however, magnetic resonance imaging demonstrated progression of the left mandibular osteosarcoma with pulmonary metastases. After multidisciplinary discussion, concurrent chemoradiotherapy was conducted. While necrotic bone segments came out of the mandible during subsequent periodic outpatient visits, the tumor itself was stable. Thirty months after his first visit and diagnosis, the patient is waiting for chemotherapy. Although CIRT is superior in treating radioresistant hypoxic disease, CIRT is in its infancy, so care must be taken for its indications and complications.
Files in This Item:
T202125403.pdf Download
DOI
10.5125/jkaoms.2021.47.4.315
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0001-6167-6475
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187826
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