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Regulation of the expression and function of TRPCs and Orai1 by Homer2 in mouse pancreatic acinar cells
DC Field | Value | Language |
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dc.contributor.author | 양유미 | - |
dc.date.accessioned | 2022-03-11T05:49:47Z | - |
dc.date.available | 2022-03-11T05:49:47Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187818 | - |
dc.description.abstract | Under physiological conditions, calcium (Ca2+) regulates essential functions of polarized secretory cells by the stimulation of specific Ca2+ signaling mechanisms, such as increases in intracellular Ca2+ concentration ([Ca2+]i) via the store-operated Ca2+ entry (SOCE) and the receptor-operated Ca2+ entry (ROCE). Homer proteins are scaffold proteins that interact with G protein-coupled receptors, inositol 1,4,5-triphosphate (IP3) receptors, Orai1-stromal interaction molecule 1, and transient receptor potential canonical (TRPC) channels. However, their role in the Ca2+ signaling in exocrine cells remains unknown. In this study, we investigated the role of Homer2 in the Ca2+ signaling and regulatory channels to mediate SOCE and ROCE in pancreatic acinar cells. Deletion of Homer2 (Homer2?/?) markedly increased the expression of TRPC3, TRPC6, and Orai1 in pancreatic acinar cells, whereas these expressions showed no difference in whole brains of wild-type and Homer2?/? mice. Furthermore, the response of Ca2+ entry by carbachol also showed significant changes to the patterns regulated by specific blockers of SOCE and ROCE in pancreatic acinar cells of Homer2?/? mice. Thus, these results suggest that Homer2 plays a critical role in the regulatory action of the [Ca2+]i via SOCE and ROCE in mouse pancreatic acinar cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Regulation of the expression and function of TRPCs and Orai1 by Homer2 in mouse pancreatic acinar cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jung Yun Kang | - |
dc.contributor.googleauthor | Namju Kang | - |
dc.contributor.googleauthor | Yu-Mi Yang | - |
dc.identifier.doi | 10.11620/IJOB.2021.46.3.134 | - |
dc.contributor.localId | A05148 | - |
dc.relation.journalcode | J01144 | - |
dc.subject.keyword | Calcium signaling | - |
dc.subject.keyword | Acinar cells | - |
dc.subject.keyword | Homer scaffolding proteins | - |
dc.subject.keyword | Physiological phenomena | - |
dc.contributor.alternativeName | Yang, Yu Mi | - |
dc.contributor.affiliatedAuthor | 양유미 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 134 | - |
dc.citation.endPage | 139 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.46(3) : 134-139, 2021-09 | - |
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