0 86

Cited 0 times in

Cytokine Release from Organotypic Human Oral Tissue Following Exposure to Oral Care Product Chemicals

DC Field Value Language
dc.contributor.author권재성-
dc.contributor.author김광만-
dc.date.accessioned2022-03-11T05:49:37Z-
dc.date.available2022-03-11T05:49:37Z-
dc.date.issued2021-12-
dc.identifier.issn2005-4742-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187816-
dc.description.abstractMeasuring viability of a three-dimensional in vitro organotypic human oral tissue model has been sug gested as an alternative test method to the oral mucosa irritation test of oral care products. The aim of this study was to investigate the production of two different cytokines using organotypic human oral tissue model following expo sure to chemicals that are commonly used in oral care products. Materials and Methods: The organotypic human oral tissues were exposed to ethanol, sodium lauryl sulphate or hydrogen peroxide for 90 minutes. Following exposure, interleukin (IL)-1α and IL-8 productions were assessed and correlated with cell viability testing as well as histology of the organotypic human oral tissues. Result: High levels of IL-8 were released from organotypic human oral tissues in all of the test and control groups without any significant differences between them. In contrast, differences were found in IL-1α release between the test and control groups. Additionally, the trend of IL-1α release corresponded to the phenotypes observed in histo logical analysis while different trend existed between IL-1α release and cell viability. Conclusion: The study concluded the non-specific release of IL-8 for the assessment of oral care product chemicals’ toxicity, while potential of measuring IL-1α cytokine level as the possible alternative test method.-
dc.description.statementOfResponsibilityprohibition-
dc.languageEnglish-
dc.publisherKorean Academy of Dental Sciences-
dc.relation.isPartOfJournal of Korean Dental Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCytokine Release from Organotypic Human Oral Tissue Following Exposure to Oral Care Product Chemicals-
dc.title.alternativeCytokine Release from Organotypic Human Oral Tissue Following Exposure to Oral Care Product Chemicals-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorSong-Yi Yang-
dc.contributor.googleauthorYin-Zhu Piao-
dc.contributor.googleauthorKWANG MAHN KIM-
dc.contributor.googleauthorJaeSung Kwon-
dc.contributor.localIdA00247-
dc.contributor.localIdA00312-
dc.relation.journalcodeJ01507-
dc.subject.keywordCytokines-
dc.subject.keywordDentistry-
dc.subject.keywordSafety-
dc.subject.keywordTissues-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor김광만-
dc.citation.volume14-
dc.citation.number2-
dc.citation.startPage51-
dc.citation.endPage60-
dc.identifier.bibliographicCitationJournal of Korean Dental Science, Vol.14(2) : 51-60, 2021-12-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.