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알츠하이머병에서 혈장 크레아틴과 염증반응, 인지기능과의 연관성

Other Titles
 Association of Plasma Creatine With Inflammation and Cognitive Function in Persons With and Without Alzheimer’s Disease 
Authors
 김민애  ;  오대종  ;  김현정  ;  조소연  ;  하정희  ;  이준영  ;  김어수  ;  김근유 
Citation
 Journal of Korean Geriatric Psychiatry(노인정신의학), Vol.25(2) : 98-104, 2021-10 
Journal Title
Journal of Korean Geriatric Psychiatry(노인정신의학)
ISSN
 1226-6329 
Issue Date
2021-10
Keywords
Creatine ; Alzheimer’s disease ; Dementia ; Cognition ; Inflammation ; C-reactive protein
Abstract
Objective: Creatine, energy buffer in high energy demanding systems including muscle and brain, may play a beneficial role
against neuroinflammation in Alzheimer’s disease (AD), and thus be a potential biomarker. This study aimed to compare the levels
of plasma creatine between persons with and without AD and investigate associations of plasma creatine levels with cognitive
function and blood-based inflammatory markers.
Methods: We classified elderly participants by cognitive statuses: normal cognition (NC, n=17), mild cognitive impairment (MCI,
n=21), and AD (n=21). To assess cognitive function and inflammatory condition, we performed neuropsychological tests and measured
plasma C-reactive protein (CRP) levels, respectively.
Results: Plasma creatine levels were comparable among participants with AD, MCI, and NC. In overall participants, plasma creatine
levels were not associated with neuropsychological test scores, but negatively associated with plasma CRP levels. In AD group,
plasma creatine levels were negatively associated with neuropsychological test scores and, although not significant, CRP levels
(p=0.086). In participants without AD (NC plus MCI), these associations disappeared.
Conclusion: Plasma creatine levels may not be useful as a biomarker indicating cognitive statuses. However, our results suggest
that, in AD, plasma levels of creatine might reflect the extent of neuroinflammation as well as cognitive deterioration.
Files in This Item:
T202125516.pdf Download
DOI
10.47825/jkgp.2021.25.2.98
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keun You(김근유) ORCID logo https://orcid.org/0000-0001-7192-2828
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
Ha, Junghee(하정희) ORCID logo https://orcid.org/0000-0002-4217-3570
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187782
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