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Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study

Authors
 Dirga Kumar Lamichhane  ;  Dal-Young Jung  ;  Yee-Jin Shin  ;  Kyung-Sook Lee  ;  So-Yeon Lee  ;  Kangmo Ahn  ;  Kyung Won Kim  ;  Youn Ho Shin  ;  Dong In Suh  ;  Soo-Jong Hong  ;  Hwan-Cheol Kim 
Citation
 INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, Vol.237 : 113823, 2021-08 
Journal Title
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
ISSN
 1438-4639 
Issue Date
2021-08
MeSH
Air Pollutants* / analysis ; Air Pollutants* / toxicity ; Air Pollution* / analysis ; Air Pollution* / statistics & numerical data ; Anxiety / epidemiology ; Cohort Studies ; Environmental Exposure / analysis ; Environmental Exposure / statistics & numerical data ; Female ; Humans ; Nitrogen Dioxide / analysis ; Nitrogen Dioxide / toxicity ; Particulate Matter / analysis ; Particulate Matter / toxicity ; Pregnancy ; Pregnant Women ; Prospective Studies
Keywords
Air pollution ; Anxiety ; Depression ; Environment ; Pregnancy
Abstract
Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown.

Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively.

Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and <10 μm (PM10), as well as to nitrogen dioxide (NO2) and ozone (O3) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM2.5, PM10, NO2, and O3 using modified Poisson regression.

Results: In single-pollutant models, an IQR increase in PM2.5, PM10, and NO2 during the second trimester was associated with an increased risk of depressive symptoms (PM2.5 RR = 1.15, 95% CI: 1.04, 1.27; PM10 RR = 1.13, 95% CI: 1.04, 1.23; NO2 RR = 1.15, 95% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O3 during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95% CI: 1.01, 1.18), while the IQR increase in O3 during the first trimester was associated with a decreased risk (RR = 0.89, 95% CI: 0.82, 0.96). Exposure to PM2.5, PM10, and NO2 during the second trimester was significantly associated with anxiety symptoms. The associations with PM2.5 and O3 in single-and multi-pollutant models were consistent.

Conclusions: Our findings indicate that increased levels of particulate matter, NO2, and O3 during pregnancy may elevate the risk of depression or anxiety in pregnant women.
Files in This Item:
T202125299.pdf Download
DOI
10.1016/j.ijheh.2021.113823
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187772
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