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Analysis of risk factors associated with survival in human epidermal growth factor receptor 2-positive ductal carcinoma in situ using Korean Breast Cancer Society Database

Authors
 Sol Ji Ahn  ;  Chang Ik Yoon  ;  Pill Sun Paik  ;  Tae-Kyung Yoo  ;  Namsun Park  ;  Eun Sook Lee  ;  Jung Eun Choi  ;  Joon Jeong  ;  Hyun Jo Youn  ;  Woo-Chan Park 
Citation
 ANNALS OF SURGICAL TREATMENT AND RESEARCH, Vol.101(6) : 315-321, 2021-12 
Journal Title
ANNALS OF SURGICAL TREATMENT AND RESEARCH
ISSN
 2288-6575 
Issue Date
2021-12
Keywords
Death ; Human epidermal growth factor receptor 2 ; Mortality ; Noninfiltrating intraductal carcinoma.
Abstract
Purpose: This study was performed to identify the risk of mortality in patients diagnosed with human epidermal growth factor receptor 2 (HER2)-positive ductal carcinoma in situ (DCIS).

Methods: We selected 2,592 patients with HER2-positive DCIS from Korean Breast Cancer Society (KBCS) database between January 1997 and December 2019. Patients who received neoadjuvant chemotherapy were excluded. Logistic regression analysis was used to determine the association between clinical factors and overall death after adjusting for tumor and clinical characteristics. Mortality data were modified using the Statistics Korea data.

Results: Thirty deaths (1.2%) were identified out of 2,592 patients in the KBCS database. In the univariate logistic regression analysis, older age, higher body mass index (BMI), type of breast surgery (mastectomy), estrogen receptor-negative, progesterone receptor-negative, and exposure to endocrine therapy were significant clinical factors associated with death. In the multivariate analysis, age (hazard ratio [HR], 1.062; 95% confidence interval [CI], 1.015-1.111; P = 0.006), BMI (HR, 1.179; 95% CI, 1.032-1.347, P = 0.016), breast surgery type (mastectomy vs. lumpectomy; HR, 0.285; 95% CI, 0.096-0.844; P = 0.024), and endocrine therapy (HR, 0.314; 95% CI, 0.099-0.995; P = 0.049) were significant risk factors for mortality.

Conclusion: Advanced age, higher BMI, mastectomy, and the absence of endocrine therapy were factors associated with poor survival of patients with HER2-positive DCIS. This finding requires further validation combined with additional analysis of large databases.
Files in This Item:
T202125133.pdf Download
DOI
10.4174/astr.2021.101.6.315
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187697
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