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Behavioral interventions to reduce particulate matter exposure in patients with COPD

Authors
 Jieun Kang  ;  Ji Ye Jung  ;  Jin-Young Huh  ;  Hyun Woo Ji  ;  Hwan-Cheol Kim  ;  Sei Won Lee 
Citation
 MEDICINE, Vol.100(49) : e28119, 2021-12 
Journal Title
MEDICINE
ISSN
 0025-7974 
Issue Date
2021-12
MeSH
Adult ; Air Pollutants / analysis* ; Air Pollution / analysis* ; Environmental Monitoring* ; Female ; Humans ; Male ; Particulate Matter / adverse effects* ; Particulate Matter / analysis ; Pulmonary Disease, Chronic Obstructive* / therapy ; Quality of Life ; Republic of Korea
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is commonly affected by particulate matter (PM) exposure. In this study, we aimed to evaluate whether behavioral interventions to reduce PM exposure improve clinical outcomes in patients with COPD.

Methods: A multicenter randomized controlled trial will be conducted involving 120 participants recruited from 3 hospitals in the capital region of the Republic of Korea. Patients aged 40 to 80 years with a diagnosis of COPD and a forced expiratory volume at 1 s <80% of the predicted value are eligible for inclusion. The participants will be randomized to either the intervention group or the usual care group (2:1). The behavioral interventions will comprise the following activities: checking air quality forecast; operating indoor air cleaners and regular check-ups of filters; ventilating the home regularly by opening windows; adhering to inhaler treatment; and refraining from going out on high air pollution days. "Internet-of-things"-based, gravimetric, and light-scattering methods will be used to measure indoor and outdoor PM concentrations. To estimate the degree of individual PM exposure, a time-activity diary and land use regression modeling will be used. The efficacy of the behavioral interventions on the following outcomes will be analyzed: amount of PM exposure, changes in forced expiratory volume at 1 s from the baseline, changes in respiratory symptoms and quality of life, risks of exacerbation, hospitalization, and death.

Discussion: Given the harmful effect of air pollutants, individual-level interventions to reduce exposure may be significant. However, there is a lack of evidence on how effective such interventions are to date. This study will be able to provide physicians and patients with evidence-based strategies to reduce PM exposure in daily life.

Trial registration number: NCT04878367.
Files in This Item:
T202125072.pdf Download
DOI
10.1097/MD.0000000000028119
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
Ji, Hyun Woo(지현우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187681
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