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Serial Detection of MYD88 L265P Mutation in the Aqueous Humor of a Patient with Vitreoretinal Lymphoma for Disease Monitoring

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dc.contributor.author김보람-
dc.contributor.author신새암-
dc.contributor.author이승규-
dc.contributor.author이승태-
dc.contributor.author이준원-
dc.contributor.author이지혜-
dc.contributor.author최성희-
dc.date.accessioned2022-02-23T01:23:59Z-
dc.date.available2022-02-23T01:23:59Z-
dc.date.issued2021-09-
dc.identifier.issn0927-3948-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187678-
dc.description.abstractPurpose: To report a case of a patient whose MYD88 mutation disappeared from the aqueous humor following treatment with intravitreal methotrexate. Methods: A retrospective review of clinical, histopathological and imaging records. Results: A 49-year-old woman presented with bilateral primary vitreoretinal lymphoma confirmed by molecular and next-generation sequencing studies on vitreous biopsy samples. Initially, the MYD88 L265P mutation was detected in aqueous samples of both eyes. Serial testing for MYD88 L265P mutations performed on aqueous samples collected at the time of the weekly intravitreal methotrexate injections showed the mutation ceased to be detected after four weekly injections in the non-vitrectomized right eye and after two weekly injections in the vitrectomized left eye. Clinical improvement accompanied the negativization of the mutation in both eyes. Conclusion: We present a case that demonstrates the possible utilization of serial testing for the MYD88 L265P mutation as a tool for monitoring disease course in vitreoretinal lymphoma.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInforma Healthcare-
dc.relation.isPartOfOCULAR IMMUNOLOGY AND INFLAMMATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntimetabolites, Antineoplastic / therapeutic use-
dc.subject.MESHAqueous Humor / metabolism*-
dc.subject.MESHDNA Mutational Analysis-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic / physiology*-
dc.subject.MESHHumans-
dc.subject.MESHIntraocular Lymphoma / drug therapy-
dc.subject.MESHIntraocular Lymphoma / genetics*-
dc.subject.MESHIntraocular Lymphoma / pathology-
dc.subject.MESHIntravitreal Injections-
dc.subject.MESHMethotrexate / therapeutic use-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation, Missense / genetics*-
dc.subject.MESHMyeloid Differentiation Factor 88 / genetics*-
dc.subject.MESHRetinal Neoplasms / drug therapy-
dc.subject.MESHRetinal Neoplasms / genetics*-
dc.subject.MESHRetinal Neoplasms / pathology-
dc.titleSerial Detection of MYD88 L265P Mutation in the Aqueous Humor of a Patient with Vitreoretinal Lymphoma for Disease Monitoring-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorSeonghee Choi-
dc.contributor.googleauthorSaeam Shin-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorJunwon Lee-
dc.contributor.googleauthorJihei Sara Lee-
dc.contributor.googleauthorBorahm Kim-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.identifier.doi10.1080/09273948.2020.1802488-
dc.contributor.localIdA05899-
dc.contributor.localIdA02108-
dc.contributor.localIdA02913-
dc.contributor.localIdA04627-
dc.contributor.localIdA03179-
dc.contributor.localIdA06116-
dc.contributor.localIdA05867-
dc.relation.journalcodeJ03485-
dc.identifier.eissn1744-5078-
dc.identifier.pmid32965155-
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/09273948.2020.1802488-
dc.subject.keywordMYD88 L265P mutation-
dc.subject.keywordVitreoretinal lymphoma-
dc.subject.keywordintravitreal methotrexate-
dc.subject.keywordposterior uveitis-
dc.subject.keywordprimary central nervous system lymphoma-
dc.contributor.alternativeNameKim, Bo Ram-
dc.contributor.affiliatedAuthor김보람-
dc.contributor.affiliatedAuthor신새암-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor이승태-
dc.contributor.affiliatedAuthor이준원-
dc.contributor.affiliatedAuthor이지혜-
dc.contributor.affiliatedAuthor최성희-
dc.citation.volume29-
dc.citation.number3-
dc.citation.startPage485-
dc.citation.endPage489-
dc.identifier.bibliographicCitationOCULAR IMMUNOLOGY AND INFLAMMATION, Vol.29(3) : 485-489, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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