Cited 5 times in
Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves' orbitopathy
DC Field | Value | Language |
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dc.contributor.author | 고재상 | - |
dc.contributor.author | 김보람 | - |
dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2022-02-23T01:22:04Z | - |
dc.date.available | 2022-02-23T01:22:04Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187660 | - |
dc.description.abstract | The roles of signal transducer and activator of transcription 3 (STAT3) in inflammation, oxidative stress, and adipogenesis during Graves' orbitopathy (GO) are incompletely understood. Here, STAT3 expression in orbital tissues (from individuals with GO and healthy control subjects) was studied, and the role of STAT3 in GO pathogenesis was examined through small-interfering RNA (siRNA)-mediated silencing in primary orbital fibroblasts. STAT3 mRNA expression was higher in GO orbital tissues than in non-GO tissues. Treatment with proinflammatory cytokines, thyroid-stimulating hormone, or insulin-like growth factor-1 induced STAT3 mRNA in GO orbital fibroblasts, but not in non-GO cells. STAT3 silencing inhibited interleukin-1β-induced inflammatory cytokines and oxidative stress-induced haem oxygenase-1 expression. STAT3 siRNA-transfected GO orbital fibroblasts showed decreased adipocyte differentiation. STAT3 affected proinflammatory cytokine production, oxidative stress responses, and adipogenesis in an in vitro model of GO, suggesting that STAT3 mediates GO pathology, and that modulating STAT3 expression may have therapeutic potential against GO. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | North Holland Publishing | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graves Ophthalmopathy / genetics* | - |
dc.subject.MESH | Graves Ophthalmopathy / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | STAT3 Transcription Factor / genetics* | - |
dc.subject.MESH | STAT3 Transcription Factor / metabolism* | - |
dc.subject.MESH | Up-Regulation* | - |
dc.subject.MESH | Young Adult . | - |
dc.title | Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves' orbitopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | JaeSang Ko | - |
dc.contributor.googleauthor | Ji-Young Kim | - |
dc.contributor.googleauthor | Bo Ram Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Don O Kikkawa | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.identifier.doi | 10.1016/j.mce.2021.111363 | - |
dc.contributor.localId | A04876 | - |
dc.contributor.localId | A05899 | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J02244 | - |
dc.identifier.eissn | 1872-8057 | - |
dc.identifier.pmid | 34116129 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0303720721002070?via%3Dihub | - |
dc.subject.keyword | Adipogenesis | - |
dc.subject.keyword | Graves' orbitopathy | - |
dc.subject.keyword | Orbital fibroblasts | - |
dc.subject.keyword | STAT3 | - |
dc.subject.keyword | Signal transducer and activator of transcription 3 | - |
dc.subject.keyword | Thyroid eye disease | - |
dc.contributor.alternativeName | Ko, Jaesang | - |
dc.contributor.affiliatedAuthor | 고재상 | - |
dc.contributor.affiliatedAuthor | 김보람 | - |
dc.contributor.affiliatedAuthor | 윤진숙 | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.citation.volume | 534 | - |
dc.citation.startPage | 111363 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol.534 : 111363, 2021-08 | - |
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