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Effect of early-life antibiotic exposure and IL-13 polymorphism on atopic dermatitis phenotype

Authors
 Min Jee Park  ;  So-Yeon Lee  ;  Si Hyeon Lee  ;  Mi-Jin Kang  ;  Kun Baek Song  ;  Sungsu Jung  ;  Ji-Sun Yoon  ;  Dong In Suh  ;  Youn Ho Shin  ;  Kyung Won Kim  ;  Kangmo Ahn  ;  Soo-Jong Hong 
Citation
 PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol.32(7) : 1445-1454, 2021-10 
Journal Title
PEDIATRIC ALLERGY AND IMMUNOLOGY
ISSN
 0905-6157 
Issue Date
2021-10
MeSH
Anti-Bacterial Agents / adverse effects ; Child ; Child, Preschool ; Dermatitis, Atopic* / drug therapy ; Dermatitis, Atopic* / epidemiology ; Dermatitis, Atopic* / genetics ; Genetic Predisposition to Disease ; Humans ; Interleukin-13* / genetics ; Phenotype ; Polymorphism, Genetic
Keywords
interleukin-13 ; antibacterial agents ; atopic ; dermatitis ; phenotype ; polymorphism
Abstract
Background: Although atopic dermatitis (AD) is associated with certain gene variants, the rapidly increasing incidence of AD suggests that environmental factors contribute to disease development. In this study, we investigated the association of AD incidence and phenotype with antibiotic exposure within 6 months of age, considering the dose administered and genetic risk.

Methods: This study included 1637 children from the COCOA cohort. Pediatric allergists assessed the presence of AD at each visit and obtained information about antibiotic exposure for more than 3 days. IL-13 (rs20541) polymorphism was genotyped by the TaqMan method. We stratified the AD phenotypes into four groups and used multinomial logistic regression models for analysis.

Results: Antibiotic exposure within 6 months of age was found to increase the risk of AD within 3 years of life (aOR = 1.40; 95% CI, 1.09-1.81) in dose-dependent manner. Antibiotic exposure more than twice increased the risk of the early-persistent AD phenotype (aOR = 2.50; 95% CI, 1.35-4.63). There was a weak interaction between genetic polymorphisms and environmental factors on the development of AD (p for interaction = 0.06). Children with the IL-13 (rs20541) GA + AA genotype have a higher risk of the early-persistent AD phenotype when exposed to antibiotics more than twice than those with the IL-13 (rs20541) GG genotype and without exposure to antibiotics (aOR = 4.73; 95% CI, 2.01-11.14).

Conclusion: Antibiotic exposure within 6 months was related to the incidence of early-persistent AD and a dose-dependent increase in the incidence of AD in childhood, whose effect was modified by the IL-13 (rs20541) genotype.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/pai.13531
DOI
10.1111/pai.13531
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187650
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