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Prenatal PM 2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

Authors
 Sangrok Kim  ;  Song-I Yang  ;  Hyeyeun Lim  ;  So-Yeon Lee  ;  Min Jee Park  ;  Kun-Baek Song  ;  Eom Ji Choi  ;  Hea Young Oh  ;  Hwan-Cheol Kim  ;  Yee-Jin Shin  ;  Kyung-Sook Lee  ;  Kil Yong Choi  ;  Dong In Suh  ;  Youn Ho Shin  ;  Kyung Won Kim  ;  Kangmo Ahn  ;  Soo-Jong Hong 
Citation
 CLINICAL AND TRANSLATIONAL ALLERGY, Vol.11(8) : e12070, 2021-10 
Journal Title
CLINICAL AND TRANSLATIONAL ALLERGY
Issue Date
2021-10
Keywords
PM2.5 ; anxiety ; atopic dermatitis ; gender ; prenatal
Abstract
Background: The prevalence of atopic dermatitis (AD) is increasing worldwide. Prenatal particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and maternal anxiety during pregnancy has been suggested as a potential causes of AD. This study investigated the effects of prenatal PM2.5 and maternal anxiety on AD and identified the critical period of PM2.5 exposure for AD in infants.

Methods: This study included 802 children from the COCOA birth cohort study with follow-up data at 1 year of age. PM2.5 was estimated by land-use regression models and prenatal anxiety was measured with a questionnaire. AD was diagnosed by doctor at 1 year of age. Logistic regression analysis and Bayesian distributed lag interaction models were applied.

Results: Higher PM2.5 during the first trimester of pregnancy, higher prenatal maternal anxiety, and male gender were associated with AD at 1 year of age (adjusted odds ratio [aOR] and 95% confidence interval [CI]: 1.86 [1.08-3.19], 1.58 [1.01-2.47], and 1.54 [1.01-2.36], respectively). Higher PM2.5 during the first trimester and higher maternal anxiety during pregnancy showed an additive effect on the risk of AD (aOR: 3.13; 95% CI: 1.56-6.28). Among boys exposed to higher maternal anxiety during pregnancy, gestational weeks 5-8 were the critical period of PM2.5 exposure for the development of AD.

Conclusions: Higher PM2.5 exposure during gestational weeks 5-8 increased the probability of AD in infancy, especially in boys with higher maternal anxiety. Avoiding PM2.5 exposure and maternal anxiety from the first trimester may prevent infant AD.
Files in This Item:
T202125014.pdf Download
DOI
10.1002/clt2.12070
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187649
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