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Prenatal PM 2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study

 Sangrok Kim  ;  Song-I Yang  ;  Hyeyeun Lim  ;  So-Yeon Lee  ;  Min Jee Park  ;  Kun-Baek Song  ;  Eom Ji Choi  ;  Hea Young Oh  ;  Hwan-Cheol Kim  ;  Yee-Jin Shin  ;  Kyung-Sook Lee  ;  Kil Yong Choi  ;  Dong In Suh  ;  Youn Ho Shin  ;  Kyung Won Kim  ;  Kangmo Ahn  ;  Soo-Jong Hong 
 CLINICAL AND TRANSLATIONAL ALLERGY, Vol.11(8) : e12070, 2021-10 
Journal Title
Issue Date
PM2.5 ; anxiety ; atopic dermatitis ; gender ; prenatal
Background: The prevalence of atopic dermatitis (AD) is increasing worldwide. Prenatal particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and maternal anxiety during pregnancy has been suggested as a potential causes of AD. This study investigated the effects of prenatal PM2.5 and maternal anxiety on AD and identified the critical period of PM2.5 exposure for AD in infants.

Methods: This study included 802 children from the COCOA birth cohort study with follow-up data at 1 year of age. PM2.5 was estimated by land-use regression models and prenatal anxiety was measured with a questionnaire. AD was diagnosed by doctor at 1 year of age. Logistic regression analysis and Bayesian distributed lag interaction models were applied.

Results: Higher PM2.5 during the first trimester of pregnancy, higher prenatal maternal anxiety, and male gender were associated with AD at 1 year of age (adjusted odds ratio [aOR] and 95% confidence interval [CI]: 1.86 [1.08-3.19], 1.58 [1.01-2.47], and 1.54 [1.01-2.36], respectively). Higher PM2.5 during the first trimester and higher maternal anxiety during pregnancy showed an additive effect on the risk of AD (aOR: 3.13; 95% CI: 1.56-6.28). Among boys exposed to higher maternal anxiety during pregnancy, gestational weeks 5-8 were the critical period of PM2.5 exposure for the development of AD.

Conclusions: Higher PM2.5 exposure during gestational weeks 5-8 increased the probability of AD in infancy, especially in boys with higher maternal anxiety. Avoiding PM2.5 exposure and maternal anxiety from the first trimester may prevent infant AD.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
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