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Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis

Authors
 Dong-Sik Chae  ;  Mi Eun Kim  ;  Kyung-Yil Kang  ;  Nae Yoon Lee  ;  Woo-Suk Lee  ;  Jun Sik Lee 
Citation
 EXPERIMENTAL AND THERAPEUTIC MEDICINE, Vol.22(6) : 1470, 2021-12 
Journal Title
EXPERIMENTAL AND THERAPEUTIC MEDICINE
ISSN
 1792-0981 
Issue Date
2021-12
Keywords
International Cartilage Repair Society ; osteoarthritis ; proteome analysis
Abstract
Osteoarthritis (OA), which is caused by joint damage, is the most common form of arthritis, affecting millions of people worldwide. This damage can accumulate over time, which is why aging is one of the main contributors to joint damage associated with OA. The OA-related proteins that have been reported to date have been identified by the comparative analysis of OA patients with normal controls, following surgical or pharmacological treatment. For the first time, the present study analyzed OA-related proteins in patients with OA according to the International Cartilage Repair Society (ICRS) scale. Changes in protein expression can be observed during the OA process. The present study demonstrated differential protein expression patterns in articular cartilage from ICRS1- and ICRS3-graded OA patients. ICRS grade-matched OA knee samples from 12 OA patients, 6 ICRS grade 1 patients and 6 ICRS3 patients were subjected to proteomic analysis using the LTQ-Orbitrap mass spectrometry system. A total of 231 unique proteins were identified as expressed across the ICRS1 and ICRS3 OA patient groups. Relative differences in protein expression associated with the following classifications were observed: Biological adhesion, cell killing, cellular process, development process and molecular function. Although some of these proteins have been previously reported to be associated with rheumatoid arthritis, including cartilage oligomeric matrix protein, collagen types, angiogenin, complement C5 and CD59 glycoprotein, numerous additional proteins were newly identified, which may further help our understanding of disease pathogenesis. These findings suggested that these proteins may be used to develop novel therapeutic targets for OA.
Files in This Item:
T202125002.pdf Download
DOI
10.3892/etm.2021.10905
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Woo Suk(이우석) ORCID logo https://orcid.org/0000-0002-0798-1660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187643
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