30 52

Cited 0 times in

High endothelial venule is a surrogate biomarker for T-cell inflamed tumor microenvironment and prognosis in gastric cancer

 Hyung Soon Park  ;  Yoo Min Kim  ;  Sewha Kim  ;  Won Suk Lee  ;  So Jung Kong  ;  Hannah Yang  ;  Beodeul Kang  ;  Jaekyung Cheon  ;  Su-Jin Shin  ;  Chan Kim  ;  Hong Jae Chon 
 JOURNAL FOR IMMUNOTHERAPY OF CANCER, Vol.9(10) : e003353, 2021-10 
Journal Title
Issue Date
Adult ; Aged ; Biomarkers / metabolism* ; Biomarkers, Tumor / metabolism* ; Humans ; Middle Aged ; Prognosis ; Stomach Neoplasms / genetics* ; Tumor Microenvironment ; Venules / immunology* ; Young Adult
gastrointestinal neoplasms ; lymphocytes ; neovascularization ; pathological ; tumor microenvironment ; tumor-infiltrating
Background: High endothelial venule (HEV) is a specialized vasculature for lymphocyte trafficking. While HEVs are frequently observed within gastric cancer (GC), the vascular-immune interaction between HEV and tumor-infiltrating lymphocytes (TILs) has not been well elucidated. In this study, we aimed to unveil the potential value of HEVs as a surrogate marker for T-cell inflamed immune microenvironment in GC using a large number of prospectively collected surgical specimens of GC.

Methods: We included 460 patients with GC who underwent surgical resection. Nanostring PanCancer immune profiling was performed to evaluate the immunological phenotype of GCs. HEV density and three distinct patterns of TILs (Crohn-like lymphoid reaction, peritumoral lymphoid reaction, and intratumoral lymphoid reaction) were analyzed for their relationship and evaluated as prognostic factors for relapse-free survival (RFS) and overall survival (OS).

Results: HEV-high GC revealed increased infiltration by immune cell subsets, including dendritic cells, CD8+ cytotoxic T cells, and CD4+ helper T cells. In addition, HEV-high GC demonstrated increased immune-modulating chemokines, type I or II interferon pathway, and immune checkpoints, all of which indicate the inflamed tumor microenvironment (TME). All three distinct patterns of TILs were associated with HEV density. In survival analysis, patients with HEV-high GC displayed significantly longer RFS and OS than those with HEV-low GC (p<0.001 for RFS, p<0.001 for OS). Multivariate analysis demonstrated that HEV was the most significant immunological prognostic factor for RFS (patients with high HEV compared with those with low HEV; HR 0.412, 95% CI 0.241 to 0.705, p=0.001) and OS (HR 0.547, 95% CI 0.329 to 0.909, p=0.02) after adjustment for age, stage, and TIL.

Conclusion: HEV is the most significant immunological prognosticator for RFS and OS in resected GC, indicating inflamed TME.
Files in This Item:
T202124875.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yoo Min(김유민)
Shin, Su Jin(신수진) ORCID logo https://orcid.org/0000-0001-9114-8438
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.