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Anxiety symptoms and mild cognitive impairment among community-dwelling older adults from low- and middle-income countries

Authors
 Lee Smith  ;  Louis Jacob  ;  Guillermo F López-Sánchez  ;  Laurie Butler  ;  Yvonne Barnett  ;  Nicola Veronese  ;  Pinar Soysal  ;  Lin Yang  ;  Igor Grabovac  ;  Mark A Tully  ;  Jae Il Shin  ;  Ai Koyanagi 
Citation
 JOURNAL OF AFFECTIVE DISORDERS, Vol.291 : 57-64, 2021-08 
Journal Title
JOURNAL OF AFFECTIVE DISORDERS
ISSN
 0165-0327 
Issue Date
2021-08
MeSH
Aged ; Anxiety ; China ; Cognitive Dysfunction* / epidemiology ; Cross-Sectional Studies ; Developing Countries* ; Female ; Ghana ; Humans ; Independent Living ; India ; Male ; Mexico / epidemiology ; Middle Aged ; Prevalence ; Russia ; South Africa
Keywords
Anxiety ; Epidemiology ; Low- and middle-income countries ; Mild cognitive impairment ; Sleep problems
Abstract
Aim: Anxiety may be a risk factor for mild cognitive impairment (MCI) but there is a scarcity of data on this association especially from low- and middle-income countries (LMICs). Thus, we investigated the association between anxiety and MCI among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa), and the mediational effect of sleep problems in this association.

Methods: Cross-sectional, community-based, nationally representative data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria. Multivariable logistic regression analysis, meta-analysis, and mediation analysis were conducted to assess associations.

Results: The final sample included 32,715 individuals aged ≥50 years with preservation in functional abilities [mean (standard deviation) age 62.1 (15.6) years; 48.3% males]. Country-wise analysis showed a positive association between anxiety and MCI in all countries (OR 1.35-14.33). The pooled estimate based on meta-analysis with random effects was OR=2.27 (95%CI=1.35-3.83). Sleep problems explained 41.1% of this association.

Conclusions: Older adults with anxiety had higher odds for MCI in LMICs. Future studies should examine whether preventing anxiety or addressing anxiety among individuals with MCI can lead to lower risk for dementia onset in LMICs, while the role of sleep problems in this association should be investigated in detail.
Full Text
https://www.sciencedirect.com/science/article/pii/S0165032721004080
DOI
10.1016/j.jad.2021.04.076
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187470
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