Cited 7 times in
RNA-dependent assembly of chimeric antigen nanoparticles as an efficient H5N1 pre-pandemic vaccine platform
DC Field | Value | Language |
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dc.contributor.author | 성백린 | - |
dc.date.accessioned | 2022-02-23T00:53:17Z | - |
dc.date.available | 2022-02-23T00:53:17Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187428 | - |
dc.description.abstract | Highly pathogenic avian influenza viruses (HPAIVs) pose a significant threat to human health, with high mortality rates, and require effective vaccines. We showed that, harnessed with novel RNA-mediated chaperone function, hemagglutinin (HA) of H5N1 HPAIV could be displayed as an immunologically relevant conformation on self-assembled chimeric nanoparticles (cNP). A tri-partite monomeric antigen was designed including: i) an RNA-interaction domain (RID) as a docking tag for RNA to enable chaperna function (chaperna: chaperone + RNA), ii) globular head domain (gd) of HA as a target antigen, and iii) ferritin as a scaffold for 24 mer-assembly. The immunization of mice with the nanoparticles (~46 nm) induced a 25-30 fold higher neutralizing capacity of the antibody and provided cross-protection from homologous and heterologous lethal challenges. This study suggests that cNP assembly is conducive to eliciting antibodies against the conserved region in HA, providing potent and broad protective efficacy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Neutralizing / immunology | - |
dc.subject.MESH | Antibodies, Neutralizing / therapeutic use | - |
dc.subject.MESH | Antibodies, Viral / immunology | - |
dc.subject.MESH | Antibodies, Viral / therapeutic use | - |
dc.subject.MESH | Birds / virology | - |
dc.subject.MESH | Hemagglutinin Glycoproteins, Influenza Virus / genetics | - |
dc.subject.MESH | Hemagglutinin Glycoproteins, Influenza Virus / immunology* | - |
dc.subject.MESH | Hemagglutinin Glycoproteins, Influenza Virus / therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Influenza A Virus, H5N1 Subtype / drug effects* | - |
dc.subject.MESH | Influenza A Virus, H5N1 Subtype / immunology | - |
dc.subject.MESH | Influenza A Virus, H5N1 Subtype / pathogenicity | - |
dc.subject.MESH | Influenza Vaccines / chemistry | - |
dc.subject.MESH | Influenza Vaccines / immunology* | - |
dc.subject.MESH | Influenza Vaccines / therapeutic use | - |
dc.subject.MESH | Influenza in Birds / immunology* | - |
dc.subject.MESH | Influenza in Birds / prevention & control | - |
dc.subject.MESH | Influenza in Birds / virology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nanoparticles / chemistry | - |
dc.subject.MESH | Nanoparticles / therapeutic use | - |
dc.subject.MESH | Pandemics | - |
dc.subject.MESH | RNA / genetics | - |
dc.subject.MESH | RNA / immunology* | - |
dc.subject.MESH | RNA / therapeutic use | - |
dc.title | RNA-dependent assembly of chimeric antigen nanoparticles as an efficient H5N1 pre-pandemic vaccine platform | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Jongkwan Lim | - |
dc.contributor.googleauthor | Yucheol Cheong | - |
dc.contributor.googleauthor | Young-Seok Kim | - |
dc.contributor.googleauthor | Wonil Chae | - |
dc.contributor.googleauthor | Beom Jeung Hwang | - |
dc.contributor.googleauthor | Jinhee Lee | - |
dc.contributor.googleauthor | Yo Han Jang | - |
dc.contributor.googleauthor | Young Hoon Roh | - |
dc.contributor.googleauthor | Sang-Uk Seo | - |
dc.contributor.googleauthor | Baik L Seong | - |
dc.identifier.doi | 10.1016/j.nano.2021.102438 | - |
dc.contributor.localId | A06211 | - |
dc.relation.journalcode | J02934 | - |
dc.identifier.eissn | 1549-9642 | - |
dc.identifier.pmid | 34256061 | - |
dc.subject.keyword | Chaperna | - |
dc.subject.keyword | Ferritin nanoparticle | - |
dc.subject.keyword | Hemagglutinin | - |
dc.subject.keyword | Influenza vaccine | - |
dc.subject.keyword | Self-assembly | - |
dc.contributor.alternativeName | Seong, Baik L | - |
dc.contributor.affiliatedAuthor | 성백린 | - |
dc.citation.volume | 37 | - |
dc.citation.startPage | 102438 | - |
dc.identifier.bibliographicCitation | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol.37 : 102438, 2021-10 | - |
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