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한국인에게서 ATP2B1 유전 변이가 비만 정도에 따른 수축기 혈압과 이완기 혈압에 미치는 영향

Other Titles
 Effects of ATP2B1 Variants on the Systolic and Diastolic Blood Pressure according to the Degree of Obesity in the South Korean Population 
 김기태  ;  김인식  ;  지선하  ;  설재웅 
 Korean Journal of Clinical Laboratory Science, Vol.52(1) : 45-52, 2020-03 
Journal Title
Korean Journal of Clinical Laboratory Science
Issue Date
ATP2B1 ; Blood pressure ; Body mass index ; Hypertension ; Single nucleotide polymorphism
Hypertension often leads to cardiovascular disease and kidney disease, and hypertention is an important worldwide problem. Body mass index (BMI) has an important role for raising blood pressure. Further, hypertension can be affected by both environmental factors and genetic factors. Many single nucleotide polymorphisms have been associated with hypertension. Genome wide association study (GWAS) is a method of confirming a new locus of increasing the risk of disease, and GWAS has confirmed several single nucleotide polymorphisms (SNPs) that are associated with high blood pressure. This study analyzed the relationship between systolic blood pressure, diastolic blood pressure and SNP of the ATP2B1 gene in 994 Koreans. SNPs that showed the highest statistical significance with systolic and diastolic blood pressures were selected on the multiple linear regression analysis. One-way analysis of variance for systolic and diastolic blood pressures was performed, and multiple logistic regression analysis was performed on the risk of hypertension. The P values were two-tailed, and P<0.05 was considered significant. Four SNPs were associated with systolic blood pressure and six SNPs were associated with diastolic blood pressure. In addition, a genotype-based analysis showed significant odds ratios for the risk of hypertension in older men (adjusted OR, 5.743; 95% CI, 1.173~28.121; P=0.031). This study suggests that the ATP2B1 variants affect both the systolic and diastolic blood pressure.
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4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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