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The validation of the dual antiplatelet therapy score in East Asians receiving percutaneous coronary intervention with exclusively second generation drug-eluting stents

Authors
 Minkwan Kim  ;  Kyung Woo Park  ;  Hak Seung Lee  ;  You-Jeong Ki  ;  Jeehoon Kang  ;  Chee-Hoon Kim  ;  Jung-Kyu Han  ;  Han-Mo Yang  ;  Hyun-Jae Kang  ;  Bon-Kwon Koo  ;  Hyo-Soo Kim 
Citation
 CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol.98(3) : E332-E341, 2021-09 
Journal Title
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
ISSN
 1522-1946 
Issue Date
2021-09
MeSH
Asian Continental Ancestry Group ; Drug Therapy, Combination ; Drug-Eluting Stents* ; Humans ; Percutaneous Coronary Intervention* / adverse effects ; Platelet Aggregation Inhibitors / adverse effects ; Risk Factors ; Time Factors ; Treatment Outcome
Keywords
blood platelets ; percutaneous coronary intervention ; platelet aggregation inhibitors ; thrombosis ; validation study
Abstract
Objectives: We investigated whether the dual antiplatelet therapy (DAPT) score (DS) predicts clinical outcome in an East-Asian population that received exclusively second generation drug-eluting stent (DES).

Backgrounds: It is uncertain whether the DS could adequately risk stratify patients exclusively receiving second generation DES.

Methods: From the Grand-DES registry, we evaluated patients who were treated with DAPT for at least 12 months and were event-free at 12 months after DES implantation. Patients were classified into two categories: high DS (≧2) (n = 3,157); and low DS (<2) (n = 5,226). The primary ischemic outcome was a composite of stent thrombosis and all myocardial infarction (MI), and the primary bleeding outcome was TIMI major or minor bleeding. A propensity score (PS)-matched analysis was done to correct for baseline differences between extended DAPT group and the conventional group.

Results: Among 8,383 subjects, the primary ischemic outcome occurred in 48 patients (0.6%) and the primary bleeding outcome in 49 patients (0.6%). High DS was associated with a higher incidence of ischemic events (ischemic outcome: 0.8% vs. 0.4%, for high vs. low DS, Log-rank p = .039), but not with any differences in bleeding events (Log-rank p = .734). In the PS-matched analysis, extended group was associated with lower risk of composite endpoint of MI, stent thrombosis, or cardiac death in only the high DS group (1.8% vs. 3.7%, Log-rank p = .004; hazard ratio 0.45, 95% confidence interval 0.27-0.76; p = .003 after adjustment).

Conclusions: The DS was an adequate risk stratifier for future ischemic events in East Asians receiving exclusively second generation DES.

Trial registration: ClinicalTrials.gov NCT03507205.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/ccd.29682
DOI
10.1002/ccd.29682
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Minkwan(김민관) ORCID logo https://orcid.org/0000-0002-4079-8219
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187332
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