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Influence of Deep Neuromuscular Blockade on Perioperative Stress Response in Patients Undergoing Robot-Assisted Gastrectomy: A Prospective Double-Blinded Randomized-Controlled Trial

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dc.contributor.author공희정-
dc.contributor.author김나영-
dc.contributor.author김명화-
dc.contributor.author배선준-
dc.contributor.author유영철-
dc.contributor.author이혜선-
dc.date.accessioned2021-12-28T17:55:05Z-
dc.date.available2021-12-28T17:55:05Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187329-
dc.description.abstractAttenuating the intraoperative stress response is crucial; however, the effect of neuromuscular blockade (NMB) on surgical stress is not completely understood. We aimed to investigate the effects of NMB on the perioperative stress response during robot-assisted gastrectomy. Patients were assigned to the deep or moderate NMB group. Serum cortisol, prolactin, and interleukin-6 (IL-6) levels and natural killer (NK) cell percentage were measured before anesthesia induction, 90 min after pneumoperitoneum, operation end (OPEnd), and postoperative day 1. Additionally, C-reactive protein (CRP) and albumin levels were estimated. Additionally, intraoperative heart rate variability was evaluated. The deep NMB group showed significantly lower levels of low-frequency/high-frequency (HF) ratio at OPEnd compared to the moderate NMB group (1.4 ± 0.2 vs. 2.2 ± 0.3, respectively; Bonferroni corrected p = 0.039). Furthermore, HF power in the deep NMB group was significantly higher at OPEnd than that in the moderate NMB group (45.2 ± 3.6 vs. 33.8 ± 4.0, respectively; Bonferroni corrected p = 0.044). However, no significant differences in cortisol, prolactin, IL-6, CRP, and albumin levels and NK cell percentage were found between the two groups. The degree of NMB may have similar effects on stress-related biological markers in patients undergoing robot-assisted gastrectomy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfJOURNAL OF PERSONALIZED MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleInfluence of Deep Neuromuscular Blockade on Perioperative Stress Response in Patients Undergoing Robot-Assisted Gastrectomy: A Prospective Double-Blinded Randomized-Controlled Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorMyoung Hwa Kim-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorYoung Chul Yoo-
dc.contributor.googleauthorHee Jung Kong-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorArim Jo-
dc.contributor.googleauthorSun Joon Bai-
dc.identifier.doi10.3390/jpm11121308-
dc.contributor.localIdA05912-
dc.contributor.localIdA00348-
dc.contributor.localIdA00429-
dc.contributor.localIdA01795-
dc.contributor.localIdA02484-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ04078-
dc.identifier.eissn2075-4426-
dc.subject.keywordneuromuscular blockade-
dc.subject.keywordrobotic surgery-
dc.subject.keywordstress response-
dc.subject.keywordpostoperative recovery-
dc.contributor.alternativeNameKong, Hee Jung-
dc.contributor.affiliatedAuthor공희정-
dc.contributor.affiliatedAuthor김나영-
dc.contributor.affiliatedAuthor김명화-
dc.contributor.affiliatedAuthor배선준-
dc.contributor.affiliatedAuthor유영철-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume11-
dc.citation.number12-
dc.citation.startPage1308-
dc.identifier.bibliographicCitationJOURNAL OF PERSONALIZED MEDICINE, Vol.11(12) : 1308, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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