Cited 5 times in
Influence of Deep Neuromuscular Blockade on Perioperative Stress Response in Patients Undergoing Robot-Assisted Gastrectomy: A Prospective Double-Blinded Randomized-Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 공희정 | - |
dc.contributor.author | 김나영 | - |
dc.contributor.author | 김명화 | - |
dc.contributor.author | 배선준 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2021-12-28T17:55:05Z | - |
dc.date.available | 2021-12-28T17:55:05Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187329 | - |
dc.description.abstract | Attenuating the intraoperative stress response is crucial; however, the effect of neuromuscular blockade (NMB) on surgical stress is not completely understood. We aimed to investigate the effects of NMB on the perioperative stress response during robot-assisted gastrectomy. Patients were assigned to the deep or moderate NMB group. Serum cortisol, prolactin, and interleukin-6 (IL-6) levels and natural killer (NK) cell percentage were measured before anesthesia induction, 90 min after pneumoperitoneum, operation end (OPEnd), and postoperative day 1. Additionally, C-reactive protein (CRP) and albumin levels were estimated. Additionally, intraoperative heart rate variability was evaluated. The deep NMB group showed significantly lower levels of low-frequency/high-frequency (HF) ratio at OPEnd compared to the moderate NMB group (1.4 ± 0.2 vs. 2.2 ± 0.3, respectively; Bonferroni corrected p = 0.039). Furthermore, HF power in the deep NMB group was significantly higher at OPEnd than that in the moderate NMB group (45.2 ± 3.6 vs. 33.8 ± 4.0, respectively; Bonferroni corrected p = 0.044). However, no significant differences in cortisol, prolactin, IL-6, CRP, and albumin levels and NK cell percentage were found between the two groups. The degree of NMB may have similar effects on stress-related biological markers in patients undergoing robot-assisted gastrectomy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF PERSONALIZED MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Influence of Deep Neuromuscular Blockade on Perioperative Stress Response in Patients Undergoing Robot-Assisted Gastrectomy: A Prospective Double-Blinded Randomized-Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Myoung Hwa Kim | - |
dc.contributor.googleauthor | Na Young Kim | - |
dc.contributor.googleauthor | Young Chul Yoo | - |
dc.contributor.googleauthor | Hee Jung Kong | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Arim Jo | - |
dc.contributor.googleauthor | Sun Joon Bai | - |
dc.identifier.doi | 10.3390/jpm11121308 | - |
dc.contributor.localId | A05912 | - |
dc.contributor.localId | A00348 | - |
dc.contributor.localId | A00429 | - |
dc.contributor.localId | A01795 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J04078 | - |
dc.identifier.eissn | 2075-4426 | - |
dc.subject.keyword | neuromuscular blockade | - |
dc.subject.keyword | robotic surgery | - |
dc.subject.keyword | stress response | - |
dc.subject.keyword | postoperative recovery | - |
dc.contributor.alternativeName | Kong, Hee Jung | - |
dc.contributor.affiliatedAuthor | 공희정 | - |
dc.contributor.affiliatedAuthor | 김나영 | - |
dc.contributor.affiliatedAuthor | 김명화 | - |
dc.contributor.affiliatedAuthor | 배선준 | - |
dc.contributor.affiliatedAuthor | 유영철 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1308 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERSONALIZED MEDICINE, Vol.11(12) : 1308, 2021-12 | - |
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