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간세포암종의 병리진단에 대한 최신 지견

Other Titles
 Up-to-date Knowledge on the Pathological Diagnosis of Hepatocellular Carcinoma 
Authors
 남지해  ;  박영년 
Citation
 Korean Journal of Gastroenterology, Vol.78(5) : 268-283, 2021-11 
Journal Title
Korean Journal of Gastroenterology
ISSN
 1598-9992 
Issue Date
2021-11
Keywords
Carcinoma, hepatocellular ; Subtype ; Pathology ; Molecular classification
Abstract
Hepatocellular carcinoma (HCC) has heterogeneous molecular and pathological features and biological behavior. Large-scale genetic studies of HCC were accumulated, and a pathological-molecular classification of HCC was proposed. Approximately 35% of HCCs can be classified into distinct histopathological subtypes according to their molecular characteristics. Among recently identified subtypes, macrotrabecular massive HCC, neutrophil-rich HCC, vessels encapsulating tumor clusters HCC, and progenitor phenotype HCC (HCC with CK19 expression) are associated with a poor prognosis, whereas the lymphocyte-rich HCC subtype is related to a better prognosis. This review provides up-to-date knowledge on the pathological diagnosis of HCC according to the updated World Health Organization Classification of Digestive System Tumors 5th ed.
DOI
10.4166/kjg.2021.140
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Nahm, Ji Hae(남지해) ORCID logo https://orcid.org/0000-0003-0902-866X
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187321
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