0 11

Cited 0 times in

TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659

Authors
 Ji-Hye Choi  ;  So M Kwon  ;  Sung U Moon  ;  Sarah Yoon  ;  Masaud Shah  ;  Byoung G Lee  ;  Jieun Yang  ;  Young N Park  ;  Hee-Jung Wang  ;  Hyun G Woo 
Citation
 LIVER INTERNATIONAL, Vol.41(11) : 2788-2800, 2021-11 
Journal Title
LIVER INTERNATIONAL
ISSN
 1478-3223 
Issue Date
2021-11
MeSH
Carcinoma, Hepatocellular* / genetics ; Cell Line, Tumor ; Cell Proliferation ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms* / genetics ; MicroRNAs* / genetics ; RNA, Antisense / genetics* ; RNA-Binding Proteins* / genetics ; RNA-Binding Proteins* / metabolism
Keywords
HCC ; RBM24 ; RNA biotype ; TPRG1-AS1 ; ceRNA ; molecular subtype
Abstract
Background & aims: Noncoding RNAs (ncRNAs) play critical roles in hepatocellular carcinoma (HCC) progression. Here, by performing RNA-sequencing (RNA-Seq) profiling, we sought to identify novel ncRNAs that potentially drive the heterogeneous progression of liver cancers.

Methods: RNA-Seq profiles were obtained from 68 HCC specimens and 10 samples of adjacent non-tumour liver tissues. The functional significance of the potential driver ncRNAs was evaluated by cell experiments.

Results: TPRG1-AS1 was identified as a potential driver noncoding RNA that promotes heterogeneous liver cancer progression. TPRG1-AS1 induced tumour suppressor RNA-binding motif protein 24 (RBM24), suppressing tumour growth by activating apoptotic tumour cell death. In addition, we report that TPRG1-AS1 acts as a competing endogenous RNA (ceRNA) for RBM24, sponging miR-4691-5p and miR-3659 to interfere with their binding to RBM24.

Conclusions: We suggest that TPRG1-AS1 is a novel ceRNA sponging miR-4691-5p and miR-3659, resulting in RBM24 expression and suppression of liver cancer growth. Our results provide new insights into the functions of ncRNAs in heterogeneous HCC progression.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/liv.15026
DOI
10.1111/liv.15026
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187320
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links