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Anti-Inflammatory Potential of Complex Extracts of Ligularia stenocephala Matsum. & Koidz. and Secale cereale L. Sprout in Chronic Gingivitis: In Vitro Investigation and Randomized Clinical Trial

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dc.contributor.author박진영-
dc.contributor.author백정원-
dc.contributor.author이중석-
dc.contributor.author차재국-
dc.contributor.author최성호-
dc.contributor.author홍인표-
dc.date.accessioned2021-12-28T17:52:02Z-
dc.date.available2021-12-28T17:52:02Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187307-
dc.description.abstractComplex extracts of Ligularia stenocephala Matsum. & Koidz. (LSE) and Secale cereale L. sprout (SCSE) (TEES-10®) were prepared. The purposes of the study were to evaluate anti-inflammatory activities of TEES-10® in vitro and to observe resolution of gingivitis in human with oral administration of TEES-10®. The effects of TEES-10® on normal periodontal ligament (PDL) cell viability, lipopolysaccharide (LPS) induced PDL cell viability and the changes of inflammatory mediator expression were evaluated in vitro. In the clinical trial, 150 mg of TEES-10® powder containing capsule was administered twice daily to the test group, while the control group administered placebos in a total 100 participants with gingivitis. Probing depth (PD), bleeding on probing (BOP), clinical attachment loss, gingival index (GI) and plaque index (PI) were measured at baseline and 4 weeks. Administering TEES-10® showed significant increase in PDL cell viability compared to administering LSE or SCSE alone. In addition, treating TEES-10® to LPS induced PDL cell significantly increased PDL cell viability compared to control. TEES-10® suppressed expression of NF-κB, p-ERK, ERK, COX-2, c-Fos and p-STAT and promoted expression of PPARγ in LPS induced PDL cells. In the clinical trial, significant improvement of GI and BOP was observed in the test group at 4 weeks. In addition, the number of patients diagnosed with gingivitis was significantly reduced in the test group at 4 weeks. Salivary MMP-8 and MMP-9 was also significantly decreased compared to placebo group. Within the limitations of this study, the TEES-10® would have an anti-inflammatory potential clinically in the chronic gingivitis patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.relation.isPartOfANTIOXIDANTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAnti-Inflammatory Potential of Complex Extracts of Ligularia stenocephala Matsum. & Koidz. and Secale cereale L. Sprout in Chronic Gingivitis: In Vitro Investigation and Randomized Clinical Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontics (치주과학교실)-
dc.contributor.googleauthorInpyo Hong-
dc.contributor.googleauthorJin-Young Park-
dc.contributor.googleauthorYoo-Hun Noh-
dc.contributor.googleauthorSu-Hee Jeon-
dc.contributor.googleauthorJeong-Won Paik-
dc.contributor.googleauthorJung-Seok Lee-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.googleauthorJae-Kook Cha-
dc.identifier.doi10.3390/antiox10101586-
dc.contributor.localIdA04749-
dc.contributor.localIdA01836-
dc.contributor.localIdA03185-
dc.contributor.localIdA04004-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ03863-
dc.identifier.eissn2076-3921-
dc.identifier.pmid34679720-
dc.subject.keywordLigularia stenocephala-
dc.subject.keywordSecale cereale-
dc.subject.keywordgingivitis-
dc.subject.keywordmedicinal plants-
dc.contributor.alternativeNamePark, Jin Young-
dc.contributor.affiliatedAuthor박진영-
dc.contributor.affiliatedAuthor백정원-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor최성호-
dc.citation.volume10-
dc.citation.number10-
dc.citation.startPage1586-
dc.identifier.bibliographicCitationANTIOXIDANTS, Vol.10(10) : 1586, 2021-10-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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