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Nephrotoxicity of cancer therapeutic drugs: Focusing on novel agents

Authors
 Min Hee Hong 
Citation
 KIDNEY RESEARCH AND CLINICAL PRACTICE, Vol.40(3) : 344-354, 2021-09 
Journal Title
KIDNEY RESEARCH AND CLINICAL PRACTICE
ISSN
 2211-9132 
Issue Date
2021-09
Keywords
Acute kidney injury ; Immune checkpoint inhibitors ; Molecularly targeted therapy ; Neoplasms ; Renal insufficiency
Abstract
Kidney injury caused by anticancer agents is a common problem that can interfere with and affect the dose intensity of anticancer therapy, thus restricting patient survival. Recent advances in targeted and immunotherapeutic agents have transformed the landscape of medical oncology, and these agents have been widely employed in clinical practice. While typically associated with favorable toxicity profiles, several novel anticancer drugs present distinctive nephrotoxicities. It remains urgent to closely monitor renal injuries associated with these agents, and medical practitioners should be familiar with general principles for managing nephrotoxicity associated with novel cancer drugs. This review provides an in-depth investigation of the literature and guidelines regarding the prevalence, clinical presentations, mechanisms, and management of nephrotoxicity for each drug.
Files in This Item:
T202105458.pdf Download
DOI
10.23876/j.krcp.21.037
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Min Hee(홍민희) ORCID logo https://orcid.org/0000-0003-3490-2195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187295
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