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Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma

Authors
 Min Ji Jeon  ;  Yea Eun Kang  ;  Jae Hoon Moon  ;  Dong Jun Lim  ;  Chang Yoon Lee  ;  Yong Sang Lee  ;  Sun Wook Kim  ;  Min-Hee Kim  ;  Bo Hyun Kim  ;  Ho-Cheol Kang  ;  Minho Shong  ;  Sun Wook Cho  ;  Won Bae Kim 
Citation
 Endocrinology and Metabolism (대한내분비학회지), Vol.36(2) : 359-364, 2021-04 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
ISSN
 2093-596X 
Issue Date
2021-04
Keywords
Active surveillance ; Cohort studies ; Comparative study ; Thyroid cancer, papillary ; Watchful waiting
Abstract
Background: A Korean Multicenter Prospective cohort study of Active Surveillance or Surgery (KoMPASS) for papillary thyroid microcarcinomas (PTMCs) has been initiated. The aim is to compare clinical outcomes between active surveillance (AS) and an immediate lobectomy for low-risk PTMCs. We here outline the detailed protocol for this study.

Methods: Adult patients with a cytopathologically confirmed PTMC sized 6.0 to 10.0 mm by ultrasound (US) will be included. Patients will be excluded if they have a suspicious extra-thyroidal extension or metastasis of a PTMC or multiple thyroid nodules or other thyroid diseases which require a total thyroidectomy. Printed material describing the prognosis of PTMCs, and the pros and cons of each management option, will be provided to eligible patients to select their preferred intervention. For the AS group, thyroid US, thyroid function, and quality of life (QoL) parameters will be monitored every 6 months during the first year, and then annually thereafter. Disease progression will be defined as a ≥3 mm increase in maximal diameter of a PTMC, or the development of new thyroid cancers or metastases. If progression is detected, patients should undergo appropriate surgery. For the lobectomy group, a lobectomy with prophylactic central neck dissection will be done within 6 months. After initial surgery, thyroid US, thyroid function, serum thyroglobulin (Tg), anti-Tg antibody, and QoL parameters will be monitored every 6 months during the first year and annually thereafter. Disease progression will be defined in these cases as the development of new thyroid cancers or metastases.

Conclusion: KoMPASS findings will help to confirm the role of AS, and develop individualized management strategies, for low-risk PTMCs.
Files in This Item:
T202105452.pdf Download
DOI
10.3803/EnM.2020.890
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187292
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