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Reduced angiovasculogenic and increased inflammatory profiles of cord blood cells in severe but not mild preeclampsia

Authors
 Seonggeon Cho  ;  Young-Doug Sohn  ;  Sangsung Kim  ;  Augustine Rajakumar  ;  Martina L Badell  ;  Neil Sidell  ;  Young-Sup Yoon 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 3630, 2021-02 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-02
MeSH
Adult ; Female ; Fetal Blood / cytology* ; Fetus / pathology ; Gene Expression Regulation ; Humans ; Inflammation / genetics ; Inflammation / pathology* ; Male ; Neovascularization, Physiologic* / genetics ; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism ; Pre-Eclampsia / pathology* ; Pregnancy
Abstract
Preeclampsia (PE) is a prevalent pregnancy disorder that leads to high maternal and fetal morbidity and mortality. While defective vascular development and angiogenesis in placenta are known as crucial pathological findings, its pathophysiological mechanism remains elusive. To better understand the effects of PE on angio-vasculogenesis and inflammatory networks in the fetus and to identify their biological signatures, we investigated the quantitative and functional characteristics of cord blood-derived mononuclear cells (CB-MNCs) and CD31-positive MNCs. Flow cytometry analysis demonstrated that the CB-MNCs from the severe PE group had significantly decreased number of cells expressing CD3, CD11b, CD14, CD19, KDR, and CD31 compared with the normal group. Quantitative real time PCR (qRT-PCR) shows down-regulation of the major angiogenic factor VEGFA in MNCs and CD31+ MNCs in severe PE. The major inflammatory cytokines IL1 was highly upregulated in CD31+ CB-MNCs in the severe PE patients. Mild PE patients, however, did not display any significant difference in expression of all measured angiogenic genes and most inflammatory genes. These findings show distinct angiogenic and inflammatory signatures from severe PE, and they may play a significant role in the pathogenesis of vascular defects in placenta of severe PE.
Files in This Item:
T202105422.pdf Download
DOI
10.1038/s41598-021-83146-8
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Yoon, Young Sup(윤영섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187274
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