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Reparative System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation Following Ischemic Stroke

DC Field Value Language
dc.contributor.author김종열-
dc.contributor.author이원택-
dc.contributor.author이종은-
dc.contributor.author정호성-
dc.contributor.author현영민-
dc.date.accessioned2021-12-28T17:44:53Z-
dc.date.available2021-12-28T17:44:53Z-
dc.date.issued2021-10-
dc.identifier.issn1868-4483-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187249-
dc.description.abstractMonocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood, and anti-inflammatory or non-classical monocytes that express CCR2lowCX3CR1high and patrol locally. In this study of transgenic mice with functional CX3CR1GFP/+ or CX3CR1GFP/+-CCR2RFP/+, we found that CCR2highCX3CR1low monocytes recruited to the injured brain were cytokine-dependently converted into CCR2lowCX3CR1high macrophages, especially under the influence of IL-4 and IL-13, thereby attenuating the neuroinflammation following sterile ischemic stroke. The overall data suggest that (1) the regulation of monocyte-switching is one of the ultimate reparative strategies in ischemic stroke, and (2) the adaptation of monocytes in a locally inflamed milieu is vital to alleviating the effects of ischemic stroke through innate immunity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfTRANSLATIONAL STROKE RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleReparative System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation Following Ischemic Stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorJoohyun Park-
dc.contributor.googleauthorJong Youl Kim-
dc.contributor.googleauthorYu Rim Kim-
dc.contributor.googleauthorMeiying Huang-
dc.contributor.googleauthorJi Young Chang-
dc.contributor.googleauthorA Young Sim-
dc.contributor.googleauthorHosung Jung-
dc.contributor.googleauthorWon Taek Lee-
dc.contributor.googleauthorYoung-Min Hyun-
dc.contributor.googleauthorJong Eun Lee-
dc.identifier.doi10.1007/s12975-020-00878-x-
dc.contributor.localIdA00923-
dc.contributor.localIdA03007-
dc.contributor.localIdA03146-
dc.contributor.localIdA03786-
dc.contributor.localIdA04814-
dc.relation.journalcodeJ04142-
dc.identifier.eissn1868-601X-
dc.identifier.pmid33409730-
dc.subject.keywordCCR2-
dc.subject.keywordCX3CR1-
dc.subject.keywordMacrophages-
dc.subject.keywordMonocytes conversion-
dc.subject.keywordNeuroinflammation ischemic stroke-
dc.contributor.alternativeNameKim, Jong Youl-
dc.contributor.affiliatedAuthor김종열-
dc.contributor.affiliatedAuthor이원택-
dc.contributor.affiliatedAuthor이종은-
dc.contributor.affiliatedAuthor정호성-
dc.contributor.affiliatedAuthor현영민-
dc.citation.volume12-
dc.citation.number5-
dc.citation.startPage879-
dc.citation.endPage893-
dc.identifier.bibliographicCitationTRANSLATIONAL STROKE RESEARCH, Vol.12(5) : 879-893, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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