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Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study

Authors
 Chang Seok Bang  ;  Ji Yong Ahn  ;  Jie-Hyun Kim  ;  Young-Il Kim  ;  Il Ju Choi  ;  Woon Geon Shin 
Citation
 JOURNAL OF MEDICAL INTERNET RESEARCH, Vol.23(4) : e25053, 2021-04 
Journal Title
JOURNAL OF MEDICAL INTERNET RESEARCH
ISSN
 1439-4456 
Issue Date
2021-04
MeSH
Artificial Intelligence ; Gastroscopy ; Humans ; Machine Learning ; Retrospective Studies ; Stomach Neoplasms* / surgery ; Treatment Outcome
Keywords
artificial intelligence ; dissection ; early gastric cancer ; endoscopic submucosal dissection ; endoscopy ; gastric cancer ; machine learning ; undifferentiated
Abstract
Background: Undifferentiated type of early gastric cancer (U-EGC) is included among the expanded indications of endoscopic submucosal dissection (ESD); however, the rate of curative resection remains unsatisfactory. Endoscopists predict the probability of curative resection by considering the size and shape of the lesion and whether ulcers are present or not. The location of the lesion, indicating the likely technical difficulty, is also considered.

Objective: The aim of this study was to establish machine learning (ML) models to better predict the possibility of curative resection in U-EGC prior to ESD.

Methods: A nationwide cohort of 2703 U-EGCs treated by ESD or surgery were adopted for the training and internal validation cohorts. Separately, an independent data set of the Korean ESD registry (n=275) and an Asan medical center data set (n=127) treated by ESD were chosen for external validation. Eighteen ML classifiers were selected to establish prediction models of curative resection with the following variables: age; sex; location, size, and shape of the lesion; and whether ulcers were present or not.

Results: Among the 18 models, the extreme gradient boosting classifier showed the best performance (internal validation accuracy 93.4%, 95% CI 90.4%-96.4%; precision 92.6%, 95% CI 89.5%-95.7%; recall 99.0%, 95% CI 97.8%-99.9%; and F1 score 95.7%, 95% CI 93.3%-98.1%). Attempts at external validation showed substantial accuracy (first external validation 81.5%, 95% CI 76.9%-86.1% and second external validation 89.8%, 95% CI 84.5%-95.1%). Lesion size was the most important feature in each explainable artificial intelligence analysis.

Conclusions: We established an ML model capable of accurately predicting the curative resection of U-EGC before ESD by considering the morphological and ecological characteristics of the lesions.
Files in This Item:
T202105296.pdf Download
DOI
10.2196/25053
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187218
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