0 391

Cited 0 times in

Sterilization of sealed PVDF pouches containing decellularized scaffold by electrical stimulation

DC Field Value Language
dc.contributor.author구민아-
dc.contributor.author박종철-
dc.contributor.author이미희-
dc.date.accessioned2021-12-28T17:38:47Z-
dc.date.available2021-12-28T17:38:47Z-
dc.date.issued2021-08-
dc.identifier.issn1860-6768-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187202-
dc.description.abstractA terminal sterilization process for tissue engineering products, such as allografts and biomaterials is necessary to ensure complete removal of pathogenic microorganisms such as the bacteria, fungi, and viruses. However, it can be difficult to sterilize allografts and artificial tissue models packaged in wet conditions without deformation. In this study, we investigated the sterilization effects of electrical stimulation (ES) and assessed its suitability by evaluating sterility assurance levels in pouches at a constant current. Stability of polyvinylidene fluoride pouches was determined by a sterility test performed after exposure to five microorganisms (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans) for 5 days; the sterility test was also performed with decellularized human dermal tissues inoculated with the five microorganisms. Sterilization using ES inactivated microorganisms both inside and outside of sealed pouches and caused no damage to the packaged tissue. Our results support the development of a novel system that involves ES sterilization for packaging of implantable biomaterials and human derived materials.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH Verlag-
dc.relation.isPartOfBIOTECHNOLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSterilization of sealed PVDF pouches containing decellularized scaffold by electrical stimulation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentOthers-
dc.contributor.googleauthorMi Hee Lee-
dc.contributor.googleauthorHaKyeong Jeong-
dc.contributor.googleauthorMin-Ah Koo-
dc.contributor.googleauthorGyeung Mi Seon-
dc.contributor.googleauthorSeung Hee Hong-
dc.contributor.googleauthorYe Jin Park-
dc.contributor.googleauthorJong-Chul Park-
dc.identifier.doi10.1002/biot.202100156-
dc.contributor.localIdA00190-
dc.contributor.localIdA01662-
dc.contributor.localIdA02777-
dc.relation.journalcodeJ00335-
dc.identifier.eissn1860-7314-
dc.identifier.pmid34374222-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/biot.202100156-
dc.subject.keyworddecellularized human dermal skin tissues-
dc.subject.keywordelectrical stimulation-
dc.subject.keywordpolyvinylidene fluoride pouch-
dc.subject.keywordsterility assurance level-
dc.subject.keywordtissue engineering products-
dc.subject.keywordwet sterilization-
dc.contributor.alternativeNameKoo, Min-Ah-
dc.contributor.affiliatedAuthor구민아-
dc.contributor.affiliatedAuthor박종철-
dc.contributor.affiliatedAuthor이미희-
dc.citation.volume16-
dc.citation.number11-
dc.citation.startPagee2100156-
dc.identifier.bibliographicCitationBIOTECHNOLOGY JOURNAL, Vol.16(11) : e2100156, 2021-08-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.