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Different prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer

DC Field Value Language
dc.contributor.author강정현-
dc.contributor.author김소영-
dc.contributor.author박은정-
dc.contributor.author백승혁-
dc.contributor.author유영훈-
dc.contributor.author이강영-
dc.contributor.author이재훈-
dc.contributor.author이혜선-
dc.contributor.author전태주-
dc.date.accessioned2021-12-28T17:35:02Z-
dc.date.available2021-12-28T17:35:02Z-
dc.date.issued2021-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187170-
dc.description.abstractThe purpose of this study was to investigate whether sex differences in visceral fat volume and glucose uptake measured by positron emission tomography/computed tomography (PET/CT) in abdominal visceral fat can stratify overall survival (OS) in patients with colorectal cancer (CRC). We retrospectively enrolled 293 patients diagnosed with CRC who underwent PET/CT before surgical resection. Fluorodeoxyglucose uptake of visceral adipose tissue (VAT-SUV) and subcutaneous adiposity tissue (SAT-SUV) were measured using PET/CT. The relative VAT (rVAT) was defined as the visceral fat volume normalized to the total volume of fat (VAT plus SAT). We defined sex-specific cutoff values for VAT-SUV, SAT-SUV, and rVAT. Univariate and multivariate analyses using Cox proportional hazard regression analysis were performed to identify the independent prognostic factors. The study population comprised 181 men and 112 women. The rVAT (0.40 vs. 0.29, p < 0.001) and VAT-SUV (0.55 vs. 0.48, p = 0.007) were significantly greater in men than in women. High rVAT (than low rVAT) and high VAT-SUV (than low VAT-SUV) showed a worse prognosis in male and female patients, respectively. Multivariate analysis indicated that the combination of rVAT and VAT-SUV was an independent prognostic factor for predicting OS in both male and female patients. The combination of rVAT and VAT-SUV could differentiate the patients with the best survival outcome from the other three individual groups in female patients, but not in males. Glucose uptake and relative volume of visceral fat may provide a new risk stratification for patients with CRC, especially female patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDifferent prognostic impact of glucose uptake in visceral adipose tissue according to sex in patients with colorectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorJae-Hoon Lee-
dc.contributor.googleauthorSoyoung Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorEun Jung Park-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorTae Joo Jeon-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorJeonghyun Kang-
dc.identifier.doi10.1038/s41598-021-01086-9-
dc.contributor.localIdA00080-
dc.contributor.localIdA05460-
dc.contributor.localIdA04572-
dc.contributor.localIdA01827-
dc.contributor.localIdA02485-
dc.contributor.localIdA02640-
dc.contributor.localIdA03093-
dc.contributor.localIdA03312-
dc.contributor.localIdA03557-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34732810-
dc.contributor.alternativeNameKang, Jeonghyun-
dc.contributor.affiliatedAuthor강정현-
dc.contributor.affiliatedAuthor김소영-
dc.contributor.affiliatedAuthor박은정-
dc.contributor.affiliatedAuthor백승혁-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor전태주-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage21556-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 21556, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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