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Baseline cognitive profile is closely associated with long-term motor prognosis in newly diagnosed Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 백경원 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.contributor.author | 이양현 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2021-12-28T17:34:00Z | - |
dc.date.available | 2021-12-28T17:34:00Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0340-5354 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187161 | - |
dc.description.abstract | Objectives: To investigate the association between cognitive function at baseline and the progression of motor disability in Parkinson's disease (PD). Methods: We consecutively enrolled 257 drug-naïve patients with early-stage PD (follow-up > 2 years) who underwent a detailed neuropsychological test at initial assessment. Factor analysis was conducted to yield four cognitive function factors and composite scores thereof: Factor 1 (visual memory/visuospatial), Factor 2 (verbal memory), Factor 3 (frontal/executive), and Factor 4 (attention/working memory/language). The global cognitive composite score of each patient was calculated based on these factors. Subsequently, we assessed the effect of baseline cognitive function on long-term motor outcomes, namely levodopa-induced dyskinesia (LID), wearing-off, freezing of gait (FOG), and rate of longitudinal increases in levodopa-equivalent dose (LED). Results: Cox regression analysis demonstrated that higher Factor 3 (frontal/executive) composite scores (i.e., better cognitive performance) were associated with early development of LID [hazard ratio (HR), 1.507; p = 0.003], whereas higher Factor 1 (visual memory/visuospatial) composite scores (i.e., better cognitive performance) were associated with a lower risk for FOG (HR 0.683; p = 0.017). We noted that higher global cognitive composite scores were associated with a lower risk for developing FOG (HR 0.455; p = 0.045). The linear mixed model demonstrated that higher global cognitive composite scores and better cognitive performance in visual memory/visuospatial function were associated with slower longitudinal increases in LED. Conclusions: These findings suggest that baseline cognitive profiles have prognostic implications on several motor aspects in patients with PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | JOURNAL OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cognition | - |
dc.subject.MESH | Disabled Persons* | - |
dc.subject.MESH | Gait Disorders, Neurologic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Motor Disorders* | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Parkinson Disease* / complications | - |
dc.subject.MESH | Parkinson Disease* / diagnosis | - |
dc.subject.MESH | Parkinson Disease* / drug therapy | - |
dc.subject.MESH | Prognosis | - |
dc.title | Baseline cognitive profile is closely associated with long-term motor prognosis in newly diagnosed Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yang Hyun Lee | - |
dc.contributor.googleauthor | KyoungWon Baik | - |
dc.contributor.googleauthor | Jin Ho Jung | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1007/s00415-021-10529-2 | - |
dc.contributor.localId | A05133 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A04603 | - |
dc.contributor.localId | A05714 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J01627 | - |
dc.identifier.eissn | 1432-1459 | - |
dc.identifier.pmid | 33942161 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00415-021-10529-2 | - |
dc.subject.keyword | Cognition | - |
dc.subject.keyword | Factor analysis | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Baik, Kyoungwon | - |
dc.contributor.affiliatedAuthor | 백경원 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 예병석 | - |
dc.contributor.affiliatedAuthor | 이양현 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 268 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 4203 | - |
dc.citation.endPage | 4212 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROLOGY, Vol.268(11) : 4203-4212, 2021-11 | - |
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