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Baseline cognitive profile is closely associated with long-term motor prognosis in newly diagnosed Parkinson's disease

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dc.contributor.author백경원-
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author이혜선-
dc.contributor.author정석종-
dc.contributor.author유한수-
dc.date.accessioned2021-12-28T17:34:00Z-
dc.date.available2021-12-28T17:34:00Z-
dc.date.issued2021-11-
dc.identifier.issn0340-5354-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187161-
dc.description.abstractObjectives: To investigate the association between cognitive function at baseline and the progression of motor disability in Parkinson's disease (PD). Methods: We consecutively enrolled 257 drug-naïve patients with early-stage PD (follow-up > 2 years) who underwent a detailed neuropsychological test at initial assessment. Factor analysis was conducted to yield four cognitive function factors and composite scores thereof: Factor 1 (visual memory/visuospatial), Factor 2 (verbal memory), Factor 3 (frontal/executive), and Factor 4 (attention/working memory/language). The global cognitive composite score of each patient was calculated based on these factors. Subsequently, we assessed the effect of baseline cognitive function on long-term motor outcomes, namely levodopa-induced dyskinesia (LID), wearing-off, freezing of gait (FOG), and rate of longitudinal increases in levodopa-equivalent dose (LED). Results: Cox regression analysis demonstrated that higher Factor 3 (frontal/executive) composite scores (i.e., better cognitive performance) were associated with early development of LID [hazard ratio (HR), 1.507; p = 0.003], whereas higher Factor 1 (visual memory/visuospatial) composite scores (i.e., better cognitive performance) were associated with a lower risk for FOG (HR 0.683; p = 0.017). We noted that higher global cognitive composite scores were associated with a lower risk for developing FOG (HR 0.455; p = 0.045). The linear mixed model demonstrated that higher global cognitive composite scores and better cognitive performance in visual memory/visuospatial function were associated with slower longitudinal increases in LED. Conclusions: These findings suggest that baseline cognitive profiles have prognostic implications on several motor aspects in patients with PD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfJOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCognition-
dc.subject.MESHDisabled Persons*-
dc.subject.MESHGait Disorders, Neurologic*-
dc.subject.MESHHumans-
dc.subject.MESHMotor Disorders*-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease* / complications-
dc.subject.MESHParkinson Disease* / diagnosis-
dc.subject.MESHParkinson Disease* / drug therapy-
dc.subject.MESHPrognosis-
dc.titleBaseline cognitive profile is closely associated with long-term motor prognosis in newly diagnosed Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorKyoungWon Baik-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorByoung Seok Ye-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1007/s00415-021-10529-2-
dc.contributor.localIdA05133-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA03312-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ01627-
dc.identifier.eissn1432-1459-
dc.identifier.pmid33942161-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00415-021-10529-2-
dc.subject.keywordCognition-
dc.subject.keywordFactor analysis-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameBaik, Kyoungwon-
dc.contributor.affiliatedAuthor백경원-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume268-
dc.citation.number11-
dc.citation.startPage4203-
dc.citation.endPage4212-
dc.identifier.bibliographicCitationJOURNAL OF NEUROLOGY, Vol.268(11) : 4203-4212, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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