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Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery

Authors
 JiYong Lee  ;  Eui Hwa Jang  ;  Jae Ho Kim  ;  SeungHyun Park  ;  Yosup Kang  ;  Sanghyun Park  ;  KangJu Lee  ;  Jung-Hwan Kim  ;  Young-Nam Youn  ;  WonHyoung Ryu 
Citation
 JOURNAL OF CONTROLLED RELEASE, Vol.340 : 125-135, 2021-12 
Journal Title
JOURNAL OF CONTROLLED RELEASE
ISSN
 0168-3659 
Issue Date
2021-12
Keywords
Intimal hyperplasia ; Microneedles ; Perivascular drug delivery ; Silk fibroin ; Vascular diseases ; Vascular wraps
Abstract
Various perivascular drug delivery techniques have been demonstrated for localized post-treatment of intimal hyperplasia: a vascular inflammatory response caused by endothelial damages. Although most perivascular devices have focused on controlling the delivery duration of anti-proliferation drug, the confined and unidirectional delivery of the drug to the target tissue has become increasingly important. In addition, careful attention should also be paid to the luminal stability and the adequate exchange of vascular protein or cell between the blood vessel and extravascular tissue to avoid any side effect from the long-term application of any perivascular device. Here, a highly flexible and porous silk fibroin microneedle wrap (Silk MN wrap) is proposed to directly inject antiproliferative drug to the anastomosis sites while ensuring sufficient vascular exchanges. Drug-embedded silk MNs were transfer-molded on a highly flexible and porous silk wrap. The enhanced cell compatibility, molecular permeability, and flexibility of silk MN wrap guaranteed the structural integrity of blood vessels. Silk wrap successfully supported the silk MNs and induced multiple MN penetration to the target tissue. Over 28 days, silk MN wrap significantly inhibited intimal hyperplasia with a 62.1% reduction in neointimal formation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0168365921005538
DOI
10.1016/j.jconrel.2021.10.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung Hwan(김정환)
Youn, Young Nam(윤영남)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187145
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