178 289

Cited 0 times in

Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies

DC Field Value Language
dc.contributor.author박민철-
dc.contributor.author백경원-
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author윤미진-
dc.contributor.author이영건-
dc.contributor.author이필휴-
dc.contributor.author전세운-
dc.contributor.author정석종-
dc.contributor.author정진호-
dc.contributor.author유한수-
dc.date.accessioned2021-12-28T17:16:07Z-
dc.date.available2021-12-28T17:16:07Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187017-
dc.description.abstractTo evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, and 18F-Florbetaben (FBB) PET. DAT- and FDG-uptake and FDG/DAT ratio were measured in the anterior and posterior striatum. The first principal component (PC1) of FDG subject residual profiles was identified for each subject. Receiver operating characteristic curve analyses for the diagnosis of DLB were performed using FDG- and DAT-PET biomarkers as predictors, and general linear models for motor severity and cognitive scores were performed adding FBB standardized uptake value ratio as a predictor. Increased metabolism in the bilateral putamen, vermis, and somato-motor cortices, which characterized PC1, was observed in the DLB group, compared to the control group. A combination of posterior putamen FDG/DAT ratio and PC1 showed the highest diagnostic accuracy (91.8% sensitivity and 96.4% specificity), which was significantly greater than that obtained by DAT uptake alone. Striatal DAT uptake and PC1 independently contributed to motor severity and language, memory, frontal/executive, and general cognitive dysfunction in DLB patients, while only PC1 contributed to attention and visuospatial dysfunction.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCognitive Dysfunction-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins*-
dc.subject.MESHHumans-
dc.subject.MESHLewy Body Disease*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.titleImplication of metabolic and dopamine transporter PET in dementia with Lewy bodies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSung Woo Kang-
dc.contributor.googleauthorSeun Jeon-
dc.contributor.googleauthorYoung-Gun Lee-
dc.contributor.googleauthorMincheol Park-
dc.contributor.googleauthorKyoungwon Baik-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorSeong Ho Jeong-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorAlan C Evans-
dc.contributor.googleauthorByoung Seok Ye-
dc.identifier.doi10.1038/s41598-021-93442-y-
dc.contributor.localIdA06165-
dc.contributor.localIdA05133-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA02550-
dc.contributor.localIdA06069-
dc.contributor.localIdA03270-
dc.contributor.localIdA06105-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34257349-
dc.contributor.alternativeNamePark, Mincheol-
dc.contributor.affiliatedAuthor박민철-
dc.contributor.affiliatedAuthor백경원-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이영건-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor전세운-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage14394-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 14394, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.