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국내 표준 삼제 요법의 제균율에 대한 체계적 문헌 고찰 및 메타분석

Other Titles
 Eradication Rates of Clarithromycin Triple Therapy in Korea: A Systematic Review and Meta-analysis 
Authors
 강승주  ;  정혜경  ;  이용찬  ;  양효준  ;  박선영  ;  신철민  ;  김성은  ;  임현철  ;  김지현  ;  남수연  ;  신운건  ;  박재명  ;  최일주  ;  김재규  ;  최미영 
Citation
 Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol.21(1) : 35-47, 2021-02 
Journal Title
Korean Journal of Helicobacter and Upper Gastrointestinal Research
ISSN
 1738-3331 
Issue Date
2021-02
Keywords
Clarithromycin ; Disease eradication ; Helicobacter pylori ; Meta-analysis
Abstract
Background/Aims
Standard triple therapy, including a proton pump inhibitor, clarithromycin, and amoxicillin, has been recommended as the first-line for Helicobacter pylori infection. However, the eradication rate of standard triple therapy has declined over the past years because of the increasing resistance to clarithromycin in Korea. We analyzed the eradication rates and the 10-year change in the eradication rates in Korea.
Methods
PubMed, EMBASE, the Cochrane Library, and KoreaMed were searched for studies published between January 2007 and June 2018. The pooled eradication rates and their 95% CIs were estimated using a random-effect logistic regression model.
Results
Twenty-six randomized controlled studies on standard triple therapy conducted in Korea were selected. The intention-to-treat (ITT) and per protocol analyses showed pooled eradication rates of standard triple therapy of 71.6% (95% CI, 69.9~73.3%) and 79.6% (95% CI, 76.6~82.2%), respectively. The eradication rate decreased with time. The ITT analysis showed that the 14-day therapy (78.1% [95% CI, 75.2~80.7%]) had significantly higher eradication rates than the 7-day therapy (70.0% [95% CI, 68.5~71.4%]) (P<0.01).
Conclusions
These results suggest that the eradication rate of standard triple therapy, as the first-line therapy, has shown an unacceptable decrease. The eradication rate increased when the duration of therapy was increased to 14 days, but it was not satisfactory. Therefore, other treatment regimens or therapies based on susceptibility tests should be considered for the first-line therapy.
Files in This Item:
T202104919.pdf Download
DOI
10.7704/kjhugr.2020.0056
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187000
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