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Association of circulating metabolites with incident type 2 diabetes in an obese population from a national cohort
DC Field | Value | Language |
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dc.contributor.author | 김정호 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 임정훈 | - |
dc.contributor.author | 임종백 | - |
dc.contributor.author | 이광섭 | - |
dc.date.accessioned | 2021-12-28T17:08:11Z | - |
dc.date.available | 2021-12-28T17:08:11Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186953 | - |
dc.description.abstract | Aims: Obesity is the most common risk factor for type 2 diabetes. However, not all obese individuals develop diabetes. In the era of precision medicine, metabolomics may reveal the fundamental metabolic status of an individual. Our aim was to assess the association of metabolites with incident type 2 diabetes in obese individuals using Korean Genome and Epidemiology Cohort Study. Methods: Using 12 years of metabolomic data from 2,580 individuals, we performed a metabolomic study to define metabolically healthy obesity in an obese population (n = 704) with incident type 2 diabetes. Cox proportional hazards regression model and survival analysis were performed adjusted for the traditional risk factors of type 2 diabetes. Results: Our study revealed that spermine, acyl-alkyl phosphatidylcholines (C34:3, C36:3, C42:1), hydroxy sphingomyelin (C22:2, C14:1), and sphingomyelin (C16:0) were associated with incident type 2 diabetes in obese individuals after the adjustment for risk factors and correction of multiple comparisons by Bonferroni method. Five metabolites (except hydroxy sphingomyelin C14:1 and sphingomyelin C16:0) were also significantly associated with incident type 2 diabetes in lean individuals. Conclusions: This study highlights the need for defining metabolically healthy obesity based on serum metabolites and elucidates potential biomarkers for type 2 diabetes in an obese population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / epidemiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Metabolomics | - |
dc.subject.MESH | Obesity / complications | - |
dc.subject.MESH | Obesity / epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Association of circulating metabolites with incident type 2 diabetes in an obese population from a national cohort | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Kwang Seob Lee | - |
dc.contributor.googleauthor | John Hoon Rim | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Jong-Baeck Lim | - |
dc.contributor.googleauthor | Jeong-Ho Kim | - |
dc.identifier.doi | 10.1016/j.diabres.2021.109077 | - |
dc.contributor.localId | A00903 | - |
dc.contributor.localId | A02810 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A04654 | - |
dc.contributor.localId | A03403 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 34599972 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168822721004368 | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.subject.keyword | Metabolomics | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Prediction | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | 김정호 | - |
dc.contributor.affiliatedAuthor | 이상국 | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.contributor.affiliatedAuthor | 임정훈 | - |
dc.contributor.affiliatedAuthor | 임종백 | - |
dc.citation.volume | 180 | - |
dc.citation.startPage | 109077 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.180 : 109077, 2021-10 | - |
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