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Cell-Membrane-Derived Nanoparticles with Notch-1 Suppressor Delivery Promote Hypoxic Cell-Cell Packing and Inhibit Angiogenesis Acting as a Two-Edged Sword
DC Field | Value | Language |
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dc.contributor.author | 김다희 | - |
dc.contributor.author | 성학준 | - |
dc.contributor.author | 신영민 | - |
dc.contributor.author | 정세용 | - |
dc.contributor.author | 이송현 | - |
dc.date.accessioned | 2021-12-28T16:54:13Z | - |
dc.date.available | 2021-12-28T16:54:13Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186843 | - |
dc.description.abstract | Cell-cell interactions regulate intracellular signaling via reciprocal contacts of cell membranes in tissue regeneration and cancer growth, indicating a critical need of membrane-derived tools in studying these processes. Hence, cell-membrane-derived nanoparticles (CMNPs) are produced using tonsil-derived mesenchymal stem cells (TMSCs) from children owing to their short doubling time. As target cell types, laryngeal cancer cells are compared to bone-marrow-derived MSCs (BMSCs) because of their cartilage damaging and chondrogenic characteristics, respectively. Treating spheroids of these cell types with CMNPs exacerbates interspheroid hypoxia with robust maintenance of the cell-cell interaction signature for 7 days. Both cell types prefer a hypoxic environment, as opposed to blood vessel formation that is absent in cartilage but is required for cancer growth. Hence, angiogenesis is inhibited by displaying the Notch-1 aptamer on CMNPs. Consequently, laryngeal cancer growth is suppressed efficiently in contrast to improved chondroprotection observed in a series of cell and animal experiments using a xenograft mouse model of laryngeal cancer. Altogether, CMNPs execute a two-edged sword function of inducing hypoxic cell-cell packing, followed by suppressing angiogenesis to promote laryngeal cancer death and chondrogenesis simultaneously. This study presents a previously unexplored therapeutic strategy for anti-cancer and chondroprotective treatment using CMNPs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isPartOf | ADVANCED MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Cell-Membrane-Derived Nanoparticles with Notch-1 Suppressor Delivery Promote Hypoxic Cell-Cell Packing and Inhibit Angiogenesis Acting as a Two-Edged Sword | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Hye-Seon Kim | - |
dc.contributor.googleauthor | Young Min Shin | - |
dc.contributor.googleauthor | Seyong Chung | - |
dc.contributor.googleauthor | Dahee Kim | - |
dc.contributor.googleauthor | Dan Bi Park | - |
dc.contributor.googleauthor | Sewoom Baek | - |
dc.contributor.googleauthor | Jeongeun Park | - |
dc.contributor.googleauthor | Si Yeong Kim | - |
dc.contributor.googleauthor | Dae-Hyun Kim | - |
dc.contributor.googleauthor | Se Won Yi | - |
dc.contributor.googleauthor | Songhyun Lee | - |
dc.contributor.googleauthor | Jung Bok Lee | - |
dc.contributor.googleauthor | Ji-Yun Ko | - |
dc.contributor.googleauthor | Gun-Il Im | - |
dc.contributor.googleauthor | Mi-Lan Kang | - |
dc.contributor.googleauthor | Hak-Joon Sung | - |
dc.identifier.doi | 10.1002/adma.202101558 | - |
dc.contributor.localId | A05812 | - |
dc.contributor.localId | A04831 | - |
dc.contributor.localId | A01958 | - |
dc.contributor.localId | A05925 | - |
dc.contributor.localId | A06179 | - |
dc.relation.journalcode | J00043 | - |
dc.identifier.eissn | 1521-4095 | - |
dc.identifier.pmid | 34431568 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/adma.202101558 | - |
dc.subject.keyword | Notch-1 aptamers | - |
dc.subject.keyword | cell membranes | - |
dc.subject.keyword | cell-cell packing | - |
dc.subject.keyword | hypoxia | - |
dc.subject.keyword | nanoparticles | - |
dc.contributor.affiliatedAuthor | 김다희 | - |
dc.contributor.affiliatedAuthor | 성학준 | - |
dc.contributor.affiliatedAuthor | 신영민 | - |
dc.contributor.affiliatedAuthor | 정세용 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 40 | - |
dc.citation.startPage | e2101558 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS, Vol.33(40) : e2101558, 2021-10 | - |
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