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Cell-Membrane-Derived Nanoparticles with Notch-1 Suppressor Delivery Promote Hypoxic Cell-Cell Packing and Inhibit Angiogenesis Acting as a Two-Edged Sword

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dc.contributor.author김다희-
dc.contributor.author성학준-
dc.contributor.author신영민-
dc.contributor.author정세용-
dc.contributor.author김다희-
dc.contributor.author성학준-
dc.contributor.author신영민-
dc.contributor.author이송현-
dc.date.accessioned2021-12-28T16:54:13Z-
dc.date.available2021-12-28T16:54:13Z-
dc.date.issued2021-10-
dc.identifier.issn0935-9648-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186843-
dc.description.abstractCell-cell interactions regulate intracellular signaling via reciprocal contacts of cell membranes in tissue regeneration and cancer growth, indicating a critical need of membrane-derived tools in studying these processes. Hence, cell-membrane-derived nanoparticles (CMNPs) are produced using tonsil-derived mesenchymal stem cells (TMSCs) from children owing to their short doubling time. As target cell types, laryngeal cancer cells are compared to bone-marrow-derived MSCs (BMSCs) because of their cartilage damaging and chondrogenic characteristics, respectively. Treating spheroids of these cell types with CMNPs exacerbates interspheroid hypoxia with robust maintenance of the cell-cell interaction signature for 7 days. Both cell types prefer a hypoxic environment, as opposed to blood vessel formation that is absent in cartilage but is required for cancer growth. Hence, angiogenesis is inhibited by displaying the Notch-1 aptamer on CMNPs. Consequently, laryngeal cancer growth is suppressed efficiently in contrast to improved chondroprotection observed in a series of cell and animal experiments using a xenograft mouse model of laryngeal cancer. Altogether, CMNPs execute a two-edged sword function of inducing hypoxic cell-cell packing, followed by suppressing angiogenesis to promote laryngeal cancer death and chondrogenesis simultaneously. This study presents a previously unexplored therapeutic strategy for anti-cancer and chondroprotective treatment using CMNPs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH-
dc.relation.isPartOfADVANCED MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCell-Membrane-Derived Nanoparticles with Notch-1 Suppressor Delivery Promote Hypoxic Cell-Cell Packing and Inhibit Angiogenesis Acting as a Two-Edged Sword-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorYoung Min Shin-
dc.contributor.googleauthorSeyong Chung-
dc.contributor.googleauthorDahee Kim-
dc.contributor.googleauthorDan Bi Park-
dc.contributor.googleauthorSewoom Baek-
dc.contributor.googleauthorJeongeun Park-
dc.contributor.googleauthorSi Yeong Kim-
dc.contributor.googleauthorDae-Hyun Kim-
dc.contributor.googleauthorSe Won Yi-
dc.contributor.googleauthorSonghyun Lee-
dc.contributor.googleauthorJung Bok Lee-
dc.contributor.googleauthorJi-Yun Ko-
dc.contributor.googleauthorGun-Il Im-
dc.contributor.googleauthorMi-Lan Kang-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1002/adma.202101558-
dc.contributor.localIdA05812-
dc.contributor.localIdA04831-
dc.contributor.localIdA01958-
dc.contributor.localIdA05925-
dc.contributor.localIdA06179-
dc.contributor.localIdA05812-
dc.contributor.localIdA04831-
dc.contributor.localIdA01958-
dc.contributor.localIdA05925-
dc.relation.journalcodeJ00043-
dc.identifier.eissn1521-4095-
dc.identifier.pmid34431568-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/adma.202101558-
dc.subject.keywordNotch-1 aptamers-
dc.subject.keywordcell membranes-
dc.subject.keywordcell-cell packing-
dc.subject.keywordhypoxia-
dc.subject.keywordnanoparticles-
dc.contributor.affiliatedAuthor김다희-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor신영민-
dc.contributor.affiliatedAuthor정세용-
dc.contributor.affiliatedAuthor김다희-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor신영민-
dc.citation.volume33-
dc.citation.number40-
dc.citation.startPagee2101558-
dc.identifier.bibliographicCitationADVANCED MATERIALS, Vol.33(40) : e2101558, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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