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Association between Fusobacterium nucleatum and patient prognosis in metastatic colon cancer

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dc.contributor.author김한상-
dc.contributor.author백순명-
dc.contributor.author안중배-
dc.contributor.author용동은-
dc.contributor.author윤상선-
dc.contributor.author이혁민-
dc.contributor.author장미-
dc.contributor.author한대훈-
dc.contributor.author한윤대-
dc.contributor.author이기쁨-
dc.date.accessioned2021-12-28T16:46:17Z-
dc.date.available2021-12-28T16:46:17Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186791-
dc.description.abstractRecent evidence suggests that Fusobacterium nucleatum (Fn) is associated with the development and progression of colorectal cancer. We aimed to delineate the clinical implications of Fn in metastatic colon cancer. We performed quantitative polymerase chain reaction (qPCR) using DNA samples from synchronous metastatic colon cancer patients with either formalin-fixed paraffin-embedded (FFPE) archival primary site tumor samples or fresh colon tissues. Progression-free survival (PFS)1 and PFS2 were defined as PFS of first- and second-line palliative settings. qPCR for Fn was successfully performed using 112 samples (FFPE, n = 61; fresh tissue, n = 51). Forty-one and 68 patients had right-sided and left-sided colon cancer, respectively. Patients with Fn enriched right-sided colon cancers had shorter PFS1 (9.7 vs. 11.2 months) than the other subgroups (HR 3.54, 95% confidence interval [CI] 1.05-11.99; P = 0.04). Fn positive right-sided colon was also associated with shorter PFS2 (3.7 vs. 6.7 months; HR 2.34, 95% CI 0.69-7.91; P = 0.04). In the univariate analysis, PFS1 was affected by differentiation and Fn positive right-sided colon cancer. The multivariate analysis showed that differentiation (HR 2.68, 95% CI 1.40-5.14, P = 0.01) and Fn positive right-sided colon (HR 0.40, 95% CI 0.18-0.88, P = 0.02) were associated with PFS1. Fn enrichment in right sided colon was not associated with overall survival (OS). Fn enrichment has significantly worse prognosis in terms of PFS1 and PFS2 in patients with right-sided metastatic colon cancers.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation between Fusobacterium nucleatum and patient prognosis in metastatic colon cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJii Bum Lee-
dc.contributor.googleauthorKyung-A Kim-
dc.contributor.googleauthorHo Yeon Cho-
dc.contributor.googleauthorDooA Kim-
dc.contributor.googleauthorWon Kyu Kim-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorSang Sun Yoon-
dc.contributor.googleauthorDai Hoon Han-
dc.contributor.googleauthorYoon Dae Han-
dc.contributor.googleauthorSoonmyung Paik-
dc.contributor.googleauthorMi Jang-
dc.contributor.googleauthorHan Sang Kim-
dc.contributor.googleauthorJoong Bae Ahn-
dc.identifier.doi10.1038/s41598-021-98941-6-
dc.contributor.localIdA01098-
dc.contributor.localIdA01823-
dc.contributor.localIdA02262-
dc.contributor.localIdA02423-
dc.contributor.localIdA02558-
dc.contributor.localIdA03286-
dc.contributor.localIdA05841-
dc.contributor.localIdA04273-
dc.contributor.localIdA04313-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34642332-
dc.contributor.alternativeNameKim, Han Sang-
dc.contributor.affiliatedAuthor김한상-
dc.contributor.affiliatedAuthor백순명-
dc.contributor.affiliatedAuthor안중배-
dc.contributor.affiliatedAuthor용동은-
dc.contributor.affiliatedAuthor윤상선-
dc.contributor.affiliatedAuthor이혁민-
dc.contributor.affiliatedAuthor장미-
dc.contributor.affiliatedAuthor한대훈-
dc.contributor.affiliatedAuthor한윤대-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage20263-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 20263, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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