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Pastable, Adhesive, Injectable, Nanofibrous, and Tunable (PAINT) Biphasic Hybrid Matrices as Versatile Therapeutic Carriers

Authors
 Seung-Hyun Kim  ;  Kyujin Hwang  ;  Haesung A Lee  ;  Joowon Kim  ;  Mira Cho  ;  Miri Kim  ;  Jeong Eun Shin  ;  Haeshin Lee  ;  Kook In Park  ;  Jae-Hyung Jang 
Citation
 ACS APPLIED MATERIALS & INTERFACES, Vol.13(36) : 42429-42441, 2021-09 
Journal Title
ACS APPLIED MATERIALS & INTERFACES
ISSN
 1944-8244 
Issue Date
2021-09
Keywords
adhesive fibers ; biphasic hybrid ; electrospun fibers ; pastable fibers ; spinal cord injury
Abstract
A critical challenge in many pharmaceutical fields is developing versatile adjuvant devices that can reduce the off-target delivery of therapeutic materials to target lesions. Herein, a biphasic hybrid fibrous system that can manipulate the spatial and temporal delivery of various therapeutic agents to target lesions by integrating multiple distinct systems and technologies such as fluffy coaxial electrospun polycaprolactone (PCL)/polystyrene (PS) fibers, cyclohexane-mediated leaching to remove PS layers selectively, amine display on PCL fibers, conjugation of naturally occurring adhesive gallol molecules onto hyaluronic acid (HA-g), and electrostatically complexing the aminated PCL fibers with the gallol-conjugated HA. In the context of "paintable" systems on target lesions, the resulting system is called a PAINT matrix (abbreviated according to the initial letter of its features: pastable, adhesive, injectable, nanofibrous, and tunable). Its viscoelastic property, which was attributed by coalescing aminated PCL fibers with viscous HA-g, enabled it to be noninvasively injected and fit into any cavity in the body with various morphologies, manually pasted on tissue surfaces, and adhered onto moisture-rich surfaces to ensure the secure delivery of therapeutics toward the target lesions. The PAINT matrix efficiently supplied immunomodulatory human neural stem cells (hNSCs) at rat hemisectioned spinal cord injury (SCI) sites and promoted both locomotive and sensory recovery in SCI models, presumably by protecting hNSCs against host immunosurveillance. The PAINT matrix will be broadly utilized for efficiently delivering therapeutics to difficult-to-reach target lesions by direct infusion or conventional biomaterial-mediated approaches due to their locations, wet surfaces, or complicated ambient environments.
Full Text
https://pubs.acs.org/doi/10.1021/acsami.1c10818
DOI
10.1021/acsami.1c10818
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Ri(김미리) ORCID logo https://orcid.org/0000-0002-0380-1677
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186760
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