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Relationship of the standard uptake value of 18 F-FDG-PET-CT with tumor-infiltrating lymphocytes in breast tumors measuring ≥ 1 cm

Authors
 Soeun Park  ;  Eun-Ki Min  ;  Soong June Bae  ;  Chihwan Cha  ;  Dooreh Kim  ;  Janghee Lee  ;  Yoon Jin Cha  ;  Sung Gwe Ahn  ;  Joon Jeong 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 12046, 2021-12 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-12
MeSH
Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Breast Neoplasms / diagnostic imaging* ; Female ; Fluorodeoxyglucose F18 / pharmacology* ; Humans ; Immune System ; Lymphocytes, Tumor-Infiltrating / cytology* ; Middle Aged ; Multivariate Analysis ; Positron Emission Tomography Computed Tomography / methods* ; Predictive Value of Tests ; Preoperative Period ; Radiopharmaceuticals / pharmacology ; Regression Analysis ; Tumor Microenvironment ; Young Adult
Abstract
Evidence suggests that tumor cells and tumor-infiltrating lymphocytes (TILs) compete for glucose in the tumor microenvironment and that tumor metabolic parameters correlate with localized immune markers in several solid tumors. We investigated the relationship of the standardized uptake value (SUV) of 18F-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG-PET-CT) with stromal TIL levels in breast cancer. We included 202 patients who underwent preoperative 18F-FDG-PET-CT and had a tumor measuring ≥ 1 cm. Maximum SUV (SUVmax) was determined using 18F-FDG-PET-CT. Multiple logistic regression was used to identify factors related to high TIL levels (≥ 40%). All tumors were treatment naïve. A significant and weak correlation existed between continuous SUVmax and continuous TIL levels (p = 0.002, R = 0.215). Tumors with high SUVmax (≥ 4) had higher mean TIL levels than those with low SUVmax (< 4). In multivariable analysis, continuous SUVmax was an independent factor associated with high TIL levels; each 1-unit increment in SUVmax corresponded to an odds ratio of 1.14 (95% confidence interval: 1.01-1.29) for high TIL levels. Our study implies that SUV is associated with TILs in breast cancer and provides clinical evidence that elevated glucose uptake by breast tumors can predict the immune system-activated tumor micromilieu.
Files in This Item:
T202102282.pdf Download
DOI
10.1038/s41598-021-91404-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dooreh(김두레)
Bae, Soong June(배숭준) ORCID logo https://orcid.org/0000-0002-0012-9694
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
Cha, Chi Hwan(차치환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186744
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