단순유방촬영사진상 군집된 미세석회화 소견;양성과 악성 병변의 조직학적 연관성

Abstract

Purpose:To evaluate differential points of clustered microcalcification in malignant and benign lesions onhistopathology and correlate with mammographic findings. Materials and Methods: Authors evaluated differentialpoints of malignant and benign calcificaitons in histopathologically confirmed 24 cases. In two patients, mappingstudies and paraffin block mammographic examinations were done to correlate calcification on mammography withhistopathologic morphology. Result: On histopathology, malignant calcifications were located in ductal lumen,while benign ones were usually located in ductal epithelium(p<0.05). However, associated three benign lesions ofthe 10 malignant lesions showed still benign calcifications adjacent to proven cancer. The typical malignantcalcifications were the shape of lamination, while benign calcifications showed granular and salty on lightmicroscope.In 2 mapping studies, malignant-looking calcifications within the area of predominant benigncalcifications yielded atypical ductal hyperplasia. Mammographic pepper,granular, punctate, salty and S-shapedcalcifications were correlated with granular and salty calcification on light microscope. Mammographic linear,branching, comma, tadpole and wormiform calcifications were correlated with histopathologic laminatedcalcification. Conclusion: Authors have recognized about characteristics of malignant Vs. benign clusteredmicrocalcifications on histopathology. Authors concluded that if malignant-looking calcification such as linear,branching, comma, tadpole and wormiform are present in an are a of predominant benign calcifications, specimenradiographic correlation and mapping study will be necessary for better demonstration of the atypical ductalhyperplasia, hidden or associated breast cancer.