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흰쥐의 난소제거후 발생한 골다공증에 대한 홍삼 사포닌의 효능

Other Titles
 Effects of Saponin on Osteoporosis Induced by Ovriectomy in Rats 
Authors
 김남현  ;  최종혁  ;  이환모 
Citation
 Journal of the Korean Orthopaedic Association (대한정형외과학회지), Vol.30(4) : 808-816, 1995-08 
Journal Title
Journal of the Korean Orthopaedic Association(대한정형외과학회지)
ISSN
 1226-2102 
Issue Date
1995-08
Abstract
Osteoporosis is defined as a pathologic condition that there occurs no change in the chemical composition of the bone, while bone resorption is abnormally increased, compared with osteogenesis, leading to a decrease in bone amount. Though many varieties of therapy have been tried, no definitely effective method has been found. Ginseng saponin is an importanat component of Korean ginseng and many studies have been performed for investigating its effectiveness. But there has been no report on saponin effects to osteoporosis. The purpose of this studies is to find out the effect of saponin in osteoporosis induced by ovariectomy in rats. For the study, 30 rats underwent sham operation(group I ) and 90 rats were ovariectomized. In group ll (30 rats), only ovariectomy was performed. In group Ⅲ (30 rats), 50mg/kg/day ginseng saponin was administered per oral route and group Ⅳ(30 rats) was administrated 150mg/kg/day saponin. All the rats were sacrificed at the 16th week. The sections of the femoral shaft were stained using Villanueva bone stain and the sections of the tibia were stained with hematoxylin-eosin. The femoral shaft and metaphyseal region were applied to compression device for measurements of bone consistency. The effect of saponin increased weight of the femur. The cross sectional area and cortical area of the femoral shaft were significantly higher in 50mg saponin group(group Ⅲ ) than osteoporosis group. But there was no significant difference in the size and number of osteoclast and the percentage of trabecular bone between saponin group(group Ⅲ ,Ⅳ)and osteoporosis group. In the biomechanical test, the consistency of cortical bone was significantly increased in 50mg saponin group than osteoporosis group. In conclusion, saponin had an effect on experimental osteoporosis induced by ovariectomy in rats. As though its precise mechanism was unknown, we considered that its action mechanism was due to osteoblastic activity resulting in a correction of bone mass deficit in osteoporotic rats.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Chong Hyuk(최종혁) ORCID logo https://orcid.org/0000-0002-9080-4904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186575
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