Adjuvant effect of polyadenylic.Polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

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Authors: Sang Jin Park ; Won Ho Kim ; Kwang Hyub Han ; Chae Yoon Chon ; Ki Baik Hahm ; Young Myoung Moon ; Jin Kyung Kang ; In Suh Park ; Jung Koo Youn

Citation: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, Vol.17(6) : 513-516, 1995-07

MeSH: Adjuvants, Immunologic / therapeutic use* ; Animals ; Antibodies, Viral / biosynthesis* ; Antibodies, Viral / drug effects ; Female ; Hepatitis B / prevention & control* ; Hepatitis B Surface Antigens / immunology* ; Mice ; Mice, Inbred BALB C ; Poly A-U / therapeutic use* ; Vaccines, Synthetic / immunology* ; Vaccines, Synthetic / therapeutic use

Abstract: The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.

Full Text: http://www.sciencedirect.com/science/article/pii/019205619500031V

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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