자궁경부암조직에서 면역조직화학염색법을 이용한 p53 및 c-erbB-2 유전자 발현의 의의

Abstract

We investigated the diagnostic usefulness of the demonstration of p53 and c-erbB-2 immunoreactivity in cervical cancers, because immuno-histochemical demonstration of p53 immunoreactivity is inexpensive, easily controlled and can be applied in routine pathology laboratories. p53 and c-erbB-2 immunoreactivity was not identified in any patients in whom there was no morphological evidence of neoplasa. In contrast, in 73% of patients of cervical cancer, p53 immunoreactivity was identified, and in 23% of patients, c-erbB-2 was identified. Overexpression of p53 gene correlates with advanced stage and large sized lision, but c-erbB-2 does not correlate with any prognostic factor.